Understanding COVID-19 vaccine uptake during pregnancy: 'Hesitance', knowledge, and evidence-based decision-making.
Understanding COVID-19 vaccine uptake during pregnancy: 'Hesitance', knowledge, and evidence-based decision-making.
复制标题
DOI：
10.1016/j.vaccine.2022.03.044
复制
发表时间：
2022-04-26
期刊：
影响因子：
5.5
通讯作者：
Swamy GK
中科院分区：
文献类型：
--
作者：
Simmons LA;Whipps MDM;Phipps JE;Satish NS;Swamy GK
COVID-19疫情的一项主要缓解策略为开发及推出疫苗。然而，怀孕和哺乳期的人没有被包括在最初的疫苗试验中，尽管美国妇产科学院和疾病控制和预防中心提出了相反的建议，但这一人群对接种疫苗犹豫不决。了解这种犹豫背后的原因对于促进疫苗接种至关重要。我们于2020年12月至2021年1月调查了加州的孕妇（n = 387），以描述对COVID-19疫苗接种的认知和决策。使用描述性回归分析，我们检查了报告COVID-19疫苗犹豫的个人的计划接种率和推理。总体而言，我们调查的加州孕妇都知道COVID-19疫苗。在387名参与者中，43%的人表示计划尽快接种疫苗。其余57%的人犹豫不决：27%的人回答说他们不会接种疫苗。一些人口统计学特征确实预测了更多的COVID-19疫苗犹豫，特别是年轻人（AOR = 0.95，p = 0.025）和生活在城市环境中（AOR = 0.80，p = 0.041）。基本工作者身份也与疫苗犹豫有关。已经接种或打算接种流感疫苗与COVID-19疫苗犹豫呈负相关（p < 0.001）。最常报道的对COVID-19疫苗犹豫不决的原因是“我对疫苗不够了解”。低水平的自我报告的知识是高度预测犹豫。“疫苗犹豫”和“抗VAX”等术语并不能充分描述有关推迟COVID-19疫苗接种的决定。相反，这些决定在很大程度上是基于缺乏关于疫苗接种对怀孕，胎儿发育和后期儿童健康影响的知识。这种知识的缺乏应该通过个人医疗保健提供者与其怀孕患者之间的对话来解决，并更好地将孕妇和儿童纳入疫苗试验。
A key mitigation strategy to the COVID-19 pandemic has been the development and roll-out of vaccines. However, pregnant and lactating people were not included in initial vaccine trials and this population is hesitant to receive the vaccine, despite contrary recommendations from the American College of Obstetrics and Gynecology and the Centers for Disease Control and Prevention. Understanding the reasons behind this hesitancy is vital to promote vaccine uptake. We surveyed pregnant people in California from December 2020 to January 2021 (n = 387) to describe cognitions and decision-making regarding COVID-19 vaccination. Using descriptive, regression-based analyses, we examined rates of planned uptake and reasoning among individuals who reported COVID-19 vaccine hesitancy. Overall, the pregnant Californians that we surveyed were aware of the COVID-19 vaccines. Of 387 participants, 43% reported planning to get the vaccine as soon as possible. The remaining 57% were hesitant: 27% responded that they would not receive the vaccine. Some demographic features did predict more COVID-19 vaccine hesitancy, particularly younger age (AOR = 0.95, p = 0.025) and living in a less urban context (AOR = 0.80, p = 0.041). Essential worker status also was associated with vaccine hesitancy. Having had, or intending to have, a flu vaccine was negatively associated with COVID-19 vaccine hesitancy (p < 0.001). The most commonly reported reason for COVID-19 vaccine hesitancy was “I don’t know enough about the vaccine.” Low levels of self-reported knowledge were highly predictive of hesitancy. Terms like “vaccine hesitance” and “anti-vax” do not adequately characterize decisions regarding delaying COVID-19 vaccination. Rather, these decisions are largely based on the lack of knowledge about the impacts of vaccination on pregnancy, fetal development, and later child wellbeing. This lack of knowledge should be countered by conversations between individual healthcare providers and their pregnant patients, and better inclusion of pregnant people and children in vaccine trials.
登录
查看更多内容
影响因子：
13.6
作者：
Skjefte M;Ngirbabul M;Akeju O;Escudero D;Hernandez-Diaz S;Wyszynski DF;Wu JW
通讯作者：
Wu JW
DOI：
10.15585/mmwr.mm6939a2
发表时间：
2020-10-02
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
Razzaghi H;Kahn KE;Black CL;Lindley MC;Jatlaoui TC;Fiebelkorn AP;Havers FP;D'Angelo DV;Cheung A;Ruther NA;Williams WW
通讯作者：
Williams WW
影响因子：
9.8
作者：
Reverby SM
通讯作者：
Reverby SM
影响因子：
7.2
作者：
Rasmussen, Sonja A.;Kelley, Colleen F.;Jamieson, Denise J.
通讯作者：
Jamieson, Denise J.
DOI：
10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Baden LR;El Sahly HM;Essink B;Kotloff K;Frey S;Novak R;Diemert D;Spector SA;Rouphael N;Creech CB;McGettigan J;Khetan S;Segall N;Solis J;Brosz A;Fierro C;Schwartz H;Neuzil K;Corey L;Gilbert P;Janes H;Follmann D;Marovich M;Mascola J;Polakowski L;Ledgerwood J;Graham BS;Bennett H;Pajon R;Knightly C;Leav B;Deng W;Zhou H;Han S;Ivarsson M;Miller J;Zaks T;COVE Study Group
通讯作者：
COVE Study Group