Towards our understanding of SARS-CoV, an emerging and devastating but quickly conquered virus.
Towards our understanding of SARS-CoV, an emerging and devastating but quickly conquered virus.
复制标题
DOI：
10.1016/j.cimid.2007.05.009
复制
发表时间：
2007-09
期刊：
影响因子：
--
通讯作者：
Gao GF
中科院分区：
文献类型：
--
作者：
Feng Y;Gao GF
严重急性呼吸综合征（Severe acute respiratory syndrome，SARS）是由新型冠状病毒（novel coronavirus，SARS-CoV）引起的一种新型传染病，目前已在30多个国家流行，发病近8400例，死亡800多人。由于前所未有的国际合作，在2003年中国南方爆发SARS的病原体被确定后不久，SARS-CoV的全基因组被成功破译。近年来，SARS冠状病毒作为一种新出现的传染性实体的病毒范例，已经从流行病学、分子病毒学/免疫学到结构基因组学进行了广泛的研究。此外，还取得了多项突破性进展，包括发现了SARS-CoV的功能性受体ACE 2，解决了SARS相关大分子的第一个晶体结构3CLpro结构，揭示了蝙蝠作为SARS样病毒的天然宿主以及果子狸可能参与SARS的出现。本文通过对SARS相关研究的回顾，重点介绍了我国SARS相关研究中具有里程碑意义的开创性研究。
Severe acute respiratory syndrome (SARS) is a newly emerging infectious disease caused by a novel coronavirus (SARS-CoV), which has overwhelmed more than 30 countries claiming nearly 8400 cases with over 800 fatalities. Thanks to the unprecedented international collaboration, the whole-genomes of SARS-CoVs were successfully deciphered shortly after the identification of the causative pathogen for outbreak of SARS in southern China, in 2003. Hitherto, the SARS-CoV, as a viral paradigm of emerging infectious entities, has been extensively studied that has ranged from epidemiology, molecular virology/immunology to structural genomics. Also, several lines of breakthroughs have been record-brokenly obtained, that included the finding of ACE2, a functional receptor for the SARS-CoV, solution of the 3CLpro structure, a first crystal structure of SARS-related macromolecules, revealing of bats as natural reservoirs for SARS-like viruses and the possible involvement of civet cats in the SARS emergence. This review intends to outline the major progress in the journey of SARS-related exploration, by emphasizing those inaugurated studies with milestone-like significance contributed by Chinese research groups.
登录
查看更多内容
杆状病毒表达的SARS-COV膜蛋白加速了昆虫细胞中凋亡的诱导。
影响因子：
3.5
作者：
Lai CW;Chan ZR;Yang DG;Lo WH;Lai YK;Chang MD;Hu YC
通讯作者：
Hu YC
影响因子：
64.8
作者：
Li W;Moore MJ;Vasilieva N;Sui J;Wong SK;Berne MA;Somasundaran M;Sullivan JL;Luzuriaga K;Greenough TC;Choe H;Farzan M
通讯作者：
Farzan M
靶向SARS-COV领导者序列的siRNA抑制病毒复制。
影响因子：
5.1
作者：
Li T;Zhang Y;Fu L;Yu C;Li X;Li Y;Zhang X;Rong Z;Wang Y;Ning H;Liang R;Chen W;Babiuk LA;Chang Z
通讯作者：
Chang Z
DOI：
10.1016/s0140-6736(03)15259-2
发表时间：
2004-01-10
期刊：
Lancet (London, England)
影响因子：
--
作者：
Guan Y;Peiris JS;Zheng B;Poon LL;Chan KH;Zeng FY;Chan CW;Chan MN;Chen JD;Chow KY;Hon CC;Hui KH;Li J;Li VY;Wang Y;Leung SW;Yuen KY;Leung FC
通讯作者：
Leung FC
影响因子：
3.8
作者：
Hai, P;Liu, YG;Rao, ZH
通讯作者：
Rao, ZH