Transmitters and pathways mediating inhibition of spinal itch-signaling neurons by scratching and other counterstimuli.
Transmitters and pathways mediating inhibition of spinal itch-signaling neurons by scratching and other counterstimuli.
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DOI：
10.1371/journal.pone.0022665
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Carstens E
中科院分区：
文献类型：
--
作者：
Akiyama T;Iodi Carstens M;Carstens E
抓挠可以缓解瘙痒，但人们对其中潜在的神经机制知之甚少。我们目前在慢性干性皮肤瘙痒小鼠模型中研究了抑制性神经递质 GABA 和甘氨酸在划痕诱发抑制脊髓瘙痒信号神经元中的作用。后爪干燥皮肤治疗同侧的浅表背角神经元表现出高水平的自发放电，该自发放电会因皮肤刮擦、捏捏和有害热而显着减弱。脊髓递送甘氨酸拮抗剂马钱子碱几乎消除了刮擦诱发的抑制作用，并且分别被GABAA和GABAB拮抗剂荷包牡丹碱和沙氯芬显着减弱。上颈脊髓的中断也会显着减弱（但不会消除）抓挠诱发的抑制作用，这表明节段和超节段回路都参与其中，这些回路通过有害的反刺激参与甘氨酸和 GABA 介导的脊髓瘙痒信号神经元的抑制。
Scratching relieves itch, but the underlying neural mechanisms are poorly understood. We presently investigated a role for the inhibitory neurotransmitters GABA and glycine in scratch-evoked inhibition of spinal itch-signaling neurons in a mouse model of chronic dry skin itch. Superficial dorsal horn neurons ipsilateral to hindpaw dry skin treatment exhibited a high level of spontaneous firing that was significantly attenuated by cutaneous scratching, pinch and noxious heat. Scratch-evoked inhibition was nearly abolished by spinal delivery of the glycine antagonist, strychnine, and was markedly attenuated by respective GABAA and GABAB antagonists bicuculline and saclofen. Scratch-evoked inhibition was also significantly attenuated (but not abolished) by interruption of the upper cervical spinal cord, indicating the involvement of both segmental and suprasegmental circuits that engage glycine- and GABA-mediated inhibition of spinal itch-signaling neurons by noxious counterstimuli.
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影响因子：
3
作者：
Lomber, SG;Payne, BR;Horel, JA
通讯作者：
Horel, JA
DOI：
10.1124/jpet.109.152256
发表时间：
2009-06-01
影响因子：
3.5
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
2.5
作者：
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通讯作者：
Carstens, E.
影响因子：
2.5
作者：
Namer, Barbara;Carr, Richard;Ringkamp, Matthias
通讯作者：
Ringkamp, Matthias