The Ror-Family Receptors in Development, Tissue Regeneration and Age-Related Disease.
The Ror-Family Receptors in Development, Tissue Regeneration and Age-Related Disease.
复制标题
Ror家族受体在发育、组织再生和乳腺癌相关疾病中的作用
DOI：
10.3389/fcell.2022.891763
复制
发表时间：
2022
影响因子：
5.5
通讯作者：
Minami, Yasuhiro
中科院分区：
文献类型：
--
作者：
Endo, Mitsuharu;Kamizaki, Koki;Minami, Yasuhiro
关键词：
Ror家族蛋白Ror 1和Ror 2作为Wnt 5a及其相关Wnt蛋白的受体或共受体，以激活非经典Wnt信号传导。Ror 1和/或Ror 2介导的信号传导在发育形态发生、组织/器官发生和损伤后成体组织再生过程中调节细胞极性、迁移、增殖和分化中起重要作用。Ror 1和Ror 2在发育中的组织中以重叠但不同的方式大量表达，并且它们在成体组织中的表达限于特定的细胞类型，例如组织干细胞/祖细胞。损伤后，成体组织中Ror 1和/或Ror 2的表达水平增加，从而促进这些损伤组织的再生或修复。另一方面，Wnt 5a-Ror 2信号传导的破坏与组织干细胞/祖细胞的衰老有关，这与衰老组织的再生能力受损有关。事实上，Ror 1和Ror 2与年龄相关的疾病有关，包括组织纤维化、动脉粥样硬化（或动脉硬化）、神经退行性疾病和癌症。在这些疾病中，观察到Ror 1和/或Ror 2的增强和/或持续（慢性）表达，并且它们可能通过Wnt 5a依赖性和非依赖性方式促进这些疾病的进展。本文综述了Ror 1和Ror 2介导的信号传导在发育、组织再生和年龄相关疾病中的作用，并讨论了其作为慢性炎症性疾病和癌症治疗靶点的潜力。
The Ror-family proteins, Ror1 and Ror2, act as receptors or co-receptors for Wnt5a and its related Wnt proteins to activate non-canonical Wnt signaling. Ror1 and/or Ror2-mediated signaling plays essential roles in regulating cell polarity, migration, proliferation and differentiation during developmental morphogenesis, tissue-/organo-genesis and regeneration of adult tissues following injury. Ror1 and Ror2 are expressed abundantly in developing tissues in an overlapping, yet distinct manner, and their expression in adult tissues is restricted to specific cell types such as tissue stem/progenitor cells. Expression levels of Ror1 and/or Ror2 in the adult tissues are increased following injury, thereby promoting regeneration or repair of these injured tissues. On the other hand, disruption of Wnt5a-Ror2 signaling is implicated in senescence of tissue stem/progenitor cells that is related to the impaired regeneration capacity of aged tissues. In fact, Ror1 and Ror2 are implicated in age-related diseases, including tissue fibrosis, atherosclerosis (or arteriosclerosis), neurodegenerative diseases, and cancers. In these diseases, enhanced and/or sustained (chronic) expression of Ror1 and/or Ror2 is observed, and they might contribute to the progression of these diseases through Wnt5a-dependent and -independent manners. In this article, we overview recent advances in our understanding of the roles of Ror1 and Ror2-mediated signaling in the development, tissue regeneration and age-related diseases, and discuss their potential to be therapeutic targets for chronic inflammatory diseases and cancers.
登录
查看更多内容
影响因子：
8.3
作者：
Arabzadeh S;Hossein G;Salehi-Dulabi Z;Zarnani AH
通讯作者：
Zarnani AH
影响因子：
6.4
作者：
Gentile, Alessandra;Lazzari, Luca;Comoglio, Paolo Maria
通讯作者：
Comoglio, Paolo Maria
影响因子：
4.8
作者：
Bai, Yan;Tan, Xungang;Zhou, Jianfeng
通讯作者：
Zhou, Jianfeng
影响因子：
5.5
作者：
Astudillo P
通讯作者：
Astudillo P
Twist 通过转录上调 ROR1 促进基底样乳腺癌的肿瘤转移
影响因子：
12.4
作者：
Cao J;Wang X;Dai T;Wu Y;Zhang M;Cao R;Zhang R;Wang G;Jiang R;Zhou BP;Shi J;Kang T
通讯作者：
Kang T