A Non-canonical Wnt Signature Correlates With Lower Survival in Gastric Cancer.
A Non-canonical Wnt Signature Correlates With Lower Survival in Gastric Cancer.
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胃癌非典型Wnt信号与低生存率相关
DOI：
10.3389/fcell.2021.633675
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发表时间：
2021
影响因子：
5.5
通讯作者：
Astudillo P
中科院分区：
文献类型：
--
作者：
Astudillo P
遗传证据提示Wnt/β-catenin通路在胃癌中的作用。然而，Wnt5a作为一种典型的非规范Wnt配体，也与该病广泛相关。因此，Wnt信号通路在胃癌发生和发展中的作用，特别是非规范Wnt通路促进胃癌发生和发展的确切机制尚不完全清楚。本文分析了公开获得的基因和蛋白表达数据，揭示了WNT5A/FZD2/FZD7/ROR2信号的存在，该信号与肿瘤浸润和间充质细胞标志物表达相关。FZD7和ROR2的高表达与共享的基因和蛋白表达谱相关，这反过来又与不良预后相关。总之，本文的研究结果提供了Wnt/β-catenin和非典型Wnt通路在胃癌中的相对贡献的最新观点。
Genetic evidence suggests a role for the Wnt/β-catenin pathway in gastric cancer. However, Wnt5a, regarded as a prototypical non-canonical Wnt ligand, has also been extensively associated with this disease. Therefore, the roles of the Wnt signaling pathway in gastric cancer initiation and progression, and particularly the precise mechanisms by which the non-canonical Wnt pathway might promote the development and progression of gastric cancer, are not entirely well understood. This article analyzes publicly available gene and protein expression data and reveals the existence of a WNT5A/FZD2/FZD7/ROR2 signature, which correlates with tumor-infiltrating and mesenchymal cell marker expression. High expression of FZD7 and ROR2 correlates with a shared gene and protein expression profile, which in turn correlates with poor prognosis. In summary, the findings presented in this article provide an updated view of the relative contributions of the Wnt/β-catenin and non-canonical Wnt pathways in gastric cancer.
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影响因子：
7.3
作者：
Gao J;Aksoy BA;Dogrusoz U;Dresdner G;Gross B;Sumer SO;Sun Y;Jacobsen A;Sinha R;Larsson E;Cerami E;Sander C;Schultz N
通讯作者：
Schultz N
DOI：
10.1097/pai.0000000000000484
发表时间：
2018-09-01
影响因子：
1.6
作者：
Jo, Yun Sol;Kim, Min Sung;Lee, Sug Hyung
通讯作者：
Lee, Sug Hyung
DOI：
10.1073/pnas.0801213105
发表时间：
2008-04-08
影响因子：
11.1
作者：
Alhopuro, Pia;Phichith, Denis;Aaltonen, Lauri A.
通讯作者：
Aaltonen, Lauri A.
影响因子：
4
作者：
Cheng, XX;Wang, ZC;Li, H
通讯作者：
Li, H
影响因子：
2.4
作者：
Elizabeth Zavala-Zendejas, Veronica;Cristina Torres-Martinez, Ana;Patricia Rendon-Huerta, Erika
通讯作者：
Patricia Rendon-Huerta, Erika