Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: A consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia.
Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: A consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia.
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DOI：
10.1002/mrm.25197
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发表时间：
2015-01
影响因子：
3.3
通讯作者：
Zaharchuk, Greg
中科院分区：
文献类型：
--
作者：
Alsop, David C.;Detre, John A.;Golay, Xavier;Guenther, Matthias;Hendrikse, Jeroen;Hernandez-Garcia, Luis;Lu, Hanzhang;MacIntosh, Bradley J.;Parkes, Laura M.;Smits, Marion;van Osch, Matthias J. P.;Wang, Danny J. J.;Wong, Eric C.;Zaharchuk, Greg
本文总结了临床应用中动脉自旋标记 (ASL) 的推荐实施方式。这是 ISMRM 灌注研究组和欧洲“ASL 痴呆症”联盟的共识，双方于 2012 年 10 月在阿姆斯特丹举行会议，达成了这一共识。尽管 ASL 继续经历快速的技术发展，但我们相信当前的 ASL 方法很强大，可以提供有用的临床信息，并且关于推荐实施的共识声明将有助于临床界采用标准化方法。在本文中，我们描述了实现 ASL 协议的主要考虑因素和权衡，并为标准方法提供了具体建议。我们的结论是，作为最佳默认实现，我们建议：伪连续标记、背景抑制、无血管挤压梯度的分段 3D 读出，以及使用简化模型以绝对单位计算和呈现标签/控制差异图像和脑血流量。
This article provides a summary statement of recommended implementations of arterial spin labeling (ASL) for clinical applications. It is a consensus of the ISMRM Perfusion Study Group and the European ‘ASL in Dementia’ consortium, both of whom met to reach this consensus in October 2012 in Amsterdam. Although ASL continues to undergo rapid technical development, we believe that current ASL methods are robust and ready to provide useful clinical information, and that a consensus statement on recommended implementations will help the clinical community to adopt a standardized approach. In this article we describe the major considerations and tradeoffs in implementing an ASL protocol, and provide specific recommendations for a standard approach. Our conclusions are that, as an optimal default implementation we recommend: pseudo-continuous labeling, background suppression, a segmented 3D readout without vascular crushing gradients, and calculation and presentation of both label/control difference images and cerebral blood flow in absolute units using a simplified model.
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