Down‐regulation of bcl‐2 expression is closely related to squamous differentiation and progesterone therapy in endometrial carcinomas
Down‐regulation of bcl‐2 expression is closely related to squamous differentiation and progesterone therapy in endometrial carcinomas
复制标题
bcl-2表达下调与子宫内膜癌鳞状分化及孕激素治疗密切相关
作者：
M. Saegusa;I. Okayasu
为了阐明 bcl-2 蛋白 (bcl-2) 表达的变化是否与分化直接相关，我们对 38 例子宫内膜癌（25 例 1 级和 13 例 2 级病例）以及 8 例黄体酮治疗后的 1 级癌的鳞状分化区域进行了免疫组织化学研究。这些分化改变的区域被细分为鳞状化生灶（Sq-M）和桑葚。还检查了雌激素和孕激素受体（ER 和 PR）的表达以及细胞增殖。 Sq-M 病灶中 bcl-2 的免疫反应性评分显着低于周围肿瘤区域，这与 ER 和 PR 染色减少以及 Ki-67 标记指数 (LI) 一致，而桑葚值处于中等水平。黄体酮治疗后，反应组的 bcl-2 免疫反应性显着下降，Ki-67 LI 和肿瘤细胞成熟度也较低。这些结果表明，在子宫内膜癌中，bcl-2表达的下调可能与鳞状细胞分化密切相关，与ER和PR表达以及细胞增殖的变化一致。此外，bcl-2 表达似乎通过肿瘤细胞成熟而被黄体酮治疗下调，表明 bcl-2 可能是临床上有用的激素治疗效果标志物。 © 1997 约翰威利父子公司。
To clarify whether changes in bcl‐2 protein (bcl‐2) expression are directly linked to differentiation, an immunohistochemical investigation was carried out on areas of squamous differentiation within 38 endometrial carcinomas (25 grade 1 and 13 grade 2 cases) as well as eight grade 1 carcinomas after progesterone therapy. Such areas of altered differentiation were subdivided into foci of squamous metaplasia (Sq‐M) and morules. Expression of oestrogen and progesterone receptors (ER and PR) and cell proliferation were also examined. Immunoreactivity scores for bcl‐2 in Sq‐M foci were significantly lower than in the surrounding tumour regions, in line with reduced staining for ER and PR and Ki‐67 labelling indices (LIs), while morule values were intermediate. After progesterone therapy, a marked decrease in bcl‐2 immunoreactivity was found in the response group, along with low Ki‐67 LIs and tumour cell maturation. These results indicate that in endometrial carcinoma, down‐regulation of bcl‐2 expression may be closely linked with squamous differentiation, in line with changes in ER and PR expression, as well as in cell proliferation. In addition, bcl‐2 expression appears to be down‐regulated by progesterone therapy through tumour cell maturation, indicating that bcl‐2 may be a clinically useful marker of hormone therapy effects. © 1997 John Wiley & Sons, Ltd.
肝细胞中氟化胆汁盐的超微结构定位。
DOI：
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发表时间：
1994
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
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作者：
Crawford,JM;Barnes,S;Stearns,RC;Hastings,CL;Godleski,JJ
通讯作者：
Godleski,JJ
DOI：
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发表时间：
1994-07
期刊：
The American journal of pathology
影响因子：
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作者：
D. Novack;S. Korsmeyer
通讯作者：
D. Novack;S. Korsmeyer
人神经母细胞瘤中 Bcl-2 癌蛋白的免疫组织化学分析。
DOI：
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发表时间：
1995
期刊：
Laboratory investigation; a journal of technical methods and pathology.
影响因子：
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作者：
Krajewski,S;Chatten,J;Hanada,M;Reed,JC
通讯作者：
Reed,JC