Two cases of pseudolymphoma on the lips

Two cases of pseudolymphoma on the lips
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嘴唇假性淋巴瘤二例

DOI:
10.1111/bjd.12837
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发表时间:
2014
影响因子:
10.3
通讯作者:
Shimizu H
Shimizu H
中科院分区:
医学1区
文献类型:
--
作者:
Haga N;Nishie W;Hata H;Miyauchi T;Muramatsu K;Kitamura S;Osawa R;Shimizu H

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患者2,42岁日本女性,有5年无症状嘴唇丘疹病史,就诊于我院。最初,皮疹时强时弱,但在初次就诊前的 4 个月内,皮疹一直持续存在(图 2a)。与患者 1 一样,她没有致病史,但注意到牙齿金属(图 2a)。病灶组织病理学显示无异型性的单核细胞弥漫性浸润,形成淋巴滤泡样结构(图2b),CD3、CD10、CD20、CD30、Bcl-6和HSV-I的免疫学特性与患者1相似(图2b)。 EBER原位杂交未显示阳性细胞(未显示)。未观察到免疫球蛋白 j 和 k 轻链限制的细胞群,针对免疫球蛋白重链基因 2 连接区域的聚合酶链反应排除了单克隆增殖(未显示)。实验室检查显示嗜酸性粒细胞增多(9μ0%;正常:0–6μ0%),抗核抗体呈阳性(9160),但血清白细胞介素2受体水平在正常范围内。我们诊断皮肤病变为 B 细胞假性淋巴瘤。患者不愿意接受
Patient 2, a 42-year-old Japanese female with a 5-year-history of asymptomatic papules on the lips, presented at our hospital. Initially, the skin eruptions waxed and waned, but for the 4 months prior to the initial visit, they had been persistent (Fig. 2a). Like patient 1, she had no causative history, but dental metal was noticed (Fig. 2a). Histopathology from a lesion showed diffuse infiltrates of mononuclear cells without atypia, which formed lymphoid follicle-like structures (Fig. 2b), and the immunological properties for CD3, CD10, CD20, CD30, Bcl-6 and HSV-I were similar to those of patient 1 (Fig. 2b). EBER in situ hybridization showed no positive cells (not shown). Immunoglobulin j and k light chain-restricted cell populations were not observed, and polymerase chain reaction targeting the joining region of the immunoglobulin heavy chain gene2 excluded monoclonal proliferation (not shown). Laboratory investigation showed increased eosinophils (9Á0%; normal: 0–6Á0%) and positivity for antinuclear antibodies (9 160), but serum interleukin-2-receptor level was within the normal limit. We diagnosed the skin lesions as B-cell pseudolymphoma. The patient did not wish to receive
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DOI: 10.1002/art.1780371006
发表时间: 1994
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