Correlation Between PPARGC1A Gene Rs8192678 G>A Polymorphism and Susceptibility To Type-2 Diabetes.
Correlation Between PPARGC1A Gene Rs8192678 G>A Polymorphism and Susceptibility To Type-2 Diabetes.
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DOI：
10.1515/biol-2019-0006
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发表时间：
2019-01
影响因子：
2.2
通讯作者：
Piao LS
中科院分区：
文献类型：
--
作者：
Du F;Yang KJ;Piao LS
系统研究过氧化物酶体增殖物激活受体γ共激活因子1α（PPARGC-1A或PGC-1 α）基因rs 8192678位点G>A多态性与2型糖尿病（T2 DM）易感性的关系。制定原始文献的纳入、排除标准和检索策略。然后，从PubMed、EMBASE和科克伦图书馆数据库中检索受试者和自由词“PPARGC 1A”、“基因多态性”和“2型糖尿病”。纳入PPARGC 1A基因rs 8192678位点G>A多态性与2型糖尿病易感性的病例对照研究。T2 DM组和对照组的病例数分别为5，607和7，596。Meta分析显示PPARGC 1A基因rs 8192678位点G>A多态性与2型糖尿病易感性相关。各组遗传模型存在差异，其中三组遗传模型差异极显著。在等位基因模型中，OR=1.249，95%CI：1.099-1.419，P=0.001。在显性遗传模型中，OR=1.364，95%CI：1.152-1.614，P=0.000。在加性遗传模型中，OR=0.828，95%CI：0.726-0.945，P=0.005。隐性遗传模型OR=1.187，95% CI：1.021-1.381，P=0.026。在西亚、南亚、欧洲和非洲人群中，PPARGC 1A基因rs 8192678位点的A等位基因可能是T2 DM的危险因素之一。
To systematically investigate the correlation between the G>A polymorphism of the peroxisome proliferator-activated receptor γ coactivator 1α (PPARGC1A or PGC-1alpha) gene rs8192678 locus and the susceptibility to type-2 diabetes mellitus (T2DM). The inclusion and exclusion criteria and retrieval strategies of original literatures were formulated. Then, subjects and free words “PPARGC1A”,”gene polymorphism”, and “T2DM” were retrieved from the PubMed, EMBASE, and Cochrane Library databases. Case-control studies on the G>A polymorphism of the PPARGC1A gene rs8192678 locus and susceptibility to T2DM were included for the meta-analysis. The number of cases in the T2DM group and control group was 5,607 and 7,596, respectively. The meta-analysis revealed that the PPARGC1A gene rs8192678 locus G>A polymorphism is associated with susceptibility to T2DM. There are differences in each group of genetic models, of which three groups of genetic models are highly significant. In the allele model, OR=1.249, 95% CI: 1.099-1.419, and P=0.001. In the dominant inheritance model, OR=1.364, 95% CI: 1.152-1.614, and P=0.000. In the additive inheritance model, OR=0.828, 95% CI: 0.726-0.945, and P=0.005. And one group is significant, in the recessive inheritance model, OR=1.187, 95% CI: 1.021-1.381, and P=0.026. In Western Asian, South Asian, European and African populations, the A allele of the PPARGC1A gene rs8192678 locus may be one of the risk factors for T2DM.
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