Role of miRNA dysregulation in sepsis.
Role of miRNA dysregulation in sepsis.
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DOI：
10.1186/s10020-022-00527-z
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发表时间：
2022-08-19
期刊：
影响因子：
--
通讯作者：
Dos Santos CC
中科院分区：
文献类型：
--
作者：
Formosa A;Turgeon P;Dos Santos CC
脓毒症被定义为继发于宿主对感染的反应失调的多系统器官功能障碍的状态，并且每年在全世界导致数百万人死亡。新的方法来对抗这种疾病是必要的，这样的工具可能预示着详细了解其分子发病机制。miRNA是靶向mRNA以抑制或降解其翻译的小RNA分子，并且在包括脓毒症在内的若干疾病过程中具有重要作用。本综述采用了一种战略方法来分析关于miRNAs和脓毒症主题的广泛文献。截至2021年1月（含），pubmed检索“miRNA或microRNA或小RNA与脓毒症未审查”，得到1140篇已审查的手稿。对233篇相关论文的内容进行了仔细审查，并确定了该主题的重要主题，随后进行了讨论，包括深入研究外周血脓毒症，髓源性抑制细胞和细胞外囊泡中失调的miRNA。我们的分析得出了重要的结论。某些miRNA，即miR-150和miR-146 a，在众多研究中在脓毒症患者的外周血中具有一致的方向性变化，强有力的数据支持在脓毒症发病机制中的作用。此外，大量文献显示了具有临床相关性的miRNA特征，最后，脓毒症中许多失调的miRNA与内皮功能障碍的过程相关。这篇综述提供了一个广泛的，最新的和详细的讨论中的作用的miRNAs在脓毒症，是为了刺激进一步的工作在该领域由于这些小miRNAs的潜力，迅速诊断，诊断和治疗机构。在线版本包含补充材料，可通过10.1186/s10020-022-00527-z获得。
Sepsis is defined as a state of multisystem organ dysfunction secondary to a dysregulated host response to infection and causes millions of deaths worldwide annually. Novel ways to counteract this disease are needed and such tools may be heralded by a detailed understanding of its molecular pathogenesis. MiRNAs are small RNA molecules that target mRNAs to inhibit or degrade their translation and have important roles in several disease processes including sepsis. The current review adopted a strategic approach to analyzing the widespread literature on the topic of miRNAs and sepsis. A pubmed search of “miRNA or microRNA or small RNA and sepsis not review” up to and including January 2021 led to 1140 manuscripts which were reviewed. Two hundred and thirty-three relevant papers were scrutinized for their content and important themes on the topic were identified and subsequently discussed, including an in-depth look at deregulated miRNAs in sepsis in peripheral blood, myeloid derived suppressor cells and extracellular vesicles. Our analysis yielded important observations. Certain miRNAs, namely miR-150 and miR-146a, have consistent directional changes in peripheral blood of septic patients across numerous studies with strong data supporting a role in sepsis pathogenesis. Furthermore, a large body of literature show miRNA signatures of clinical relevance, and lastly, many miRNAs deregulated in sepsis are associated with the process of endothelial dysfunction. This review offers a widespread, up-to-date and detailed discussion of the role of miRNAs in sepsis and is meant to stimulate further work in the field due to the potential of these small miRNAs in prompt diagnostics, prognostication and therapeutic agency. The online version contains supplementary material available at 10.1186/s10020-022-00527-z.
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DOI：
10.1186/cc5055
发表时间：
2006
期刊：
Critical care (London, England)
影响因子：
--
作者：
Cavaillon JM;Adib-Conquy M
通讯作者：
Adib-Conquy M
影响因子：
4.6
作者：
Caserta S;Kern F;Cohen J;Drage S;Newbury SF;Llewelyn MJ
通讯作者：
Llewelyn MJ
影响因子：
5.1
作者：
Buie, Joy N. Jones;Zhou, Yue;Fan, Hongkuan
通讯作者：
Fan, Hongkuan
影响因子：
11.1
作者：
Balusu S;Van Wonterghem E;De Rycke R;Raemdonck K;Stremersch S;Gevaert K;Brkic M;Demeestere D;Vanhooren V;Hendrix A;Libert C;Vandenbroucke RE
通讯作者：
Vandenbroucke RE
影响因子：
3.4
作者：
Beg MS;Brenner AJ;Sachdev J;Borad M;Kang YK;Stoudemire J;Smith S;Bader AG;Kim S;Hong DS
通讯作者：
Hong DS