Bench-to-bedside review: endotoxin tolerance as a model of leukocyte reprogramming in sepsis.
Bench-to-bedside review: endotoxin tolerance as a model of leukocyte reprogramming in sepsis.
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DOI：
10.1186/cc5055
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Adib-Conquy M
中科院分区：
文献类型：
--
作者：
Cavaillon JM;Adib-Conquy M
内毒素耐受性定义为首次接触内毒素后对脂多糖（LPS）攻击的反应性降低。内毒素耐受性保护抵抗LPS的致死性攻击并防止感染和缺血再灌注损伤。内毒素耐受性通过响应于LPS的肿瘤坏死因子（TNF）和一些其它细胞因子的产生的显著减少而被破坏。内毒素耐受涉及巨噬细胞和介质的参与，如糖皮质激素、白介素、IL-10和转化生长因子-β。内毒素耐受性伴随着抑制性分子的上调，所述抑制性分子下调Toll样受体（TLR）4依赖性信号传导途径。LPS和其他TLR特异性配体以及IL-1和TNF之间的交叉耐受性已被定期报道。在脓毒症患者和非感染性全身炎症反应综合征（SIRS）患者的循环白细胞中反复报道了类似的LPS反应性丧失。对脓毒症和SIRS患者白细胞内细胞信号传导的研究揭示了许多变化，这些变化使人联想到在内毒素耐受细胞中观察到的变化。然而，脓毒症和SIRS患者的白细胞对LPS的反应性改变并不等同于细胞反应性的全面下调。术语“细胞重编程”，已被提出来限定内毒素耐受的过程，很好地定义了脓毒症和SIRS患者中循环白细胞的免疫状态。
Endotoxin tolerance is defined as a reduced responsiveness to a lipopolysaccharide (LPS) challenge following a first encounter with endotoxin. Endotoxin tolerance protects against a lethal challenge of LPS and prevents infection and ischemia-reperfusion damage. Endotoxin tolerance is paralleled by a dramatic reduction of tumor necrosis factor (TNF) production and some other cytokines in response to LPS. Endotoxin tolerance involves the participation of macrophages and mediators, such as glucocorticoids, prostaglandins, IL-10, and transforming growth factor-β. Endotoxin tolerance is accompanied by the up-regulation of inhibitory molecules that down-regulate the Toll-like receptor (TLR)4-dependent signaling pathway. Cross-tolerance between LPS and other TLR specific ligands, as well as IL-1 and TNF, has been regularly reported. A similar loss of LPS reactivity has been repeatedly reported in circulating leukocytes of septic patients and in patients with non-infectious systemic inflammation response syndrome (SIRS). Studies on cellular signaling within leukocytes from septic and SIRS patients reveal numerous alterations reminiscent of those observed in endotoxin tolerant cells. However, altered responsiveness to LPS of leukocytes from sepsis and SIRS patients is not synonymous with a global down-regulation of cellular reactivity. The term 'cellular reprogramming', which has been proposed to qualify the process of endotoxin tolerance, defines well the immune status of circulating leukocytes in septic and SIRS patients.
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影响因子：
2.2
作者：
COLLETTI, LM;REMICK, DG;CAMPBELL, DA
通讯作者：
CAMPBELL, DA
影响因子：
9
作者：
CONSTANTIAN, MB
通讯作者：
CONSTANTIAN, MB
影响因子：
37.8
作者：
Adrie, C;Adib-Conquy, M;Cavaillon, JM
通讯作者：
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影响因子：
32.4
作者：
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影响因子：
30.5
作者：
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通讯作者：
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