Biomechanical properties of Achilles tendon repair augmented with a bioadhesive-coated scaffold.
Biomechanical properties of Achilles tendon repair augmented with a bioadhesive-coated scaffold.
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DOI：
10.1088/1748-6041/6/1/015014
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发表时间：
2011-02
期刊：
影响因子：
--
通讯作者：
Lee BP
中科院分区：
文献类型：
--
作者：
Brodie M;Vollenweider L;Murphy JL;Xu F;Lyman A;Lew WD;Lee BP
跟腱是最常见的肌腱断裂。急性和慢性（被忽视的）肌腱断裂都会极大地影响患者的生活质量，并且在恢复到损伤前的活动水平之前需要长时间的恢复。本文描述了使用粘合剂涂层生物支架来加强横断跟腱的一期缝合修复。粘合剂部分由贻贝粘合蛋白的合成模拟物组成，其可以在潮湿环境中粘附到各种表面，包括生物组织。当与生物支架（如牛心包或猪真皮组织）结合时，这些粘合剂结构表现出的搭接剪切粘合强度显著大于纤维蛋白胶，同时达到氰基丙烯酸酯基粘合剂强度的60%。将这些粘合剂结构包裹在用平行和三环缝合模式组合修复的横断尸体猪跟腱周围。与单独缝合修复的对照肌腱相比，加固修复的拉伸力学测试显示出显著更高的刚度（22-34%）、失效载荷（24-44%）和失效能量（27-63%）。这种新型的粘合剂生物材料的潜在临床意义进行了讨论。
The Achilles tendon is the most frequently ruptured tendon. Both acute and chronic (neglected) tendon ruptures can dramatically affect a patient’s quality of life, and require a prolonged period of recovery before return to pre-injury activity levels. This paper describes the use of an adhesive-coated biologic scaffold to augment primary suture repair of transected Achilles tendons. The adhesive portion consisted of a synthetic mimic of mussel adhesive proteins that can adhere to various surfaces in a wet environment, including biologic tissues. When combined with biologic scaffolds such as bovine pericardium or porcine dermal tissues, these adhesive constructs demonstrated lap shear adhesive strengths significantly greater than that of fibrin glue, while reaching up to 60% of the strength of a cyanoacrylate-based adhesive. These adhesive constructs were wrapped around transected cadaveric porcine Achilles tendons repaired with a combination of parallel and three-loop suture patterns. Tensile mechanical testing of the augmented repairs exhibited significantly higher stiffness (22–34%), failure load (24–44%), and energy to failure (27–63%) when compared to control tendons with suture repair alone. Potential clinical implications of this novel adhesive biomaterial are discussed.
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影响因子：
14
作者：
Brubaker, Carrie E.;Kissler, Hermann;Wang, Ling-Jia;Kaufman, Dixon B.;Messersmith, Phillip B.
通讯作者：
Messersmith, Phillip B.
影响因子：
9.6
作者：
Korenkov, M;Sauerland, S;Troidl, H
通讯作者：
Troidl, H
DOI：
10.1053/j.jfas.2007.05.007
发表时间：
2007-11-01
期刊：
The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
影响因子：
--
作者：
Lee, Daniel K
通讯作者：
Lee, Daniel K
DOI：
10.1054/jhsb.1999.0279
发表时间：
1999-12-01
期刊：
JOURNAL OF HAND SURGERY-BRITISH AND EUROPEAN VOLUME
影响因子：
--
作者：
Evans, CE;Lees, GC;Trail, IA
通讯作者：
Trail, IA
影响因子：
2.3
作者：
Herbort, Mirco;Haber, Axel;Petersen, Wolf
通讯作者：
Petersen, Wolf