Complex regulation of the T cell receptor alpha gene: three different modes of triggering induction.
Complex regulation of the T cell receptor alpha gene: three different modes of triggering induction.
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T 细胞受体 α 基因的复杂调节：三种不同的触发诱导模式。
DOI：
10.1002/eji.1830180607
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发表时间：
1988
影响因子：
5.4
通讯作者：
MacLeod,CL
中科院分区：
文献类型：
--
作者：
Wilkinson,MF;MacLeod,CL
The T cell receptor (TcR) for antigen is composed of variable α and β subunits in noncovalent association with the invariant T3 multimer. TcR/T3 transcripts accumulate in a specific sequence during T cell development; TcR α transcripts are the last in the series to accumulate. To explore the regulation of TcR α gene expression, we investigated a T lymphoma cell clone which constitutively expresses TcR β, T3 † and T3 e mRNA, but essentially lacks detectable TcR α mRNA. The cell clone can be induced to accumulate substantial amounts of TcR α mRNA in response to phorbol myristate acetate (PMA) or calcium ionophore A23187. Two different protein synthesis inhibitors also induce TcR α mRNA. The following evidence indicates that PMA, A23187 and cycloheximide induce TcR α by different mechanisms: (a) treatment with a combination of two agents induces greater than additive amounts of TcR a mRNA than that induced by a single agent; (b) the immunosuppresent cyclosporin A specifically inhibits A23187‐mediated TcR α mRNA induction, whereas it fails to inhibit PMA or cycloheximide‐mediated induction; and (c) both A23187 and PMA increase the rate of TcR α gene transcription, while cycloheximide influences TcR α mRNA accumulation by post‐transcriptional mechanisms.
冷处理对同步中国仓鼠细胞有丝分裂的影响
影响因子：
5.6
作者：
H. Nagasawa;W. Dewey
通讯作者：
W. Dewey
同步中国仓鼠卵巢细胞中 8-氮鸟嘌呤抗性突变体的 X 射线诱导。
影响因子：
3.4
作者：
R. Jostes;K. Bushnell;W. Dewey
通讯作者：
W. Dewey