Dietary calcium and vitamin K are associated with osteoporotic fracture risk in middle-aged and elderly Japanese women, but not men: the Murakami Cohort Study
Dietary calcium and vitamin K are associated with osteoporotic fracture risk in middle-aged and elderly Japanese women, but not men: the Murakami Cohort Study
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膳食钙和维生素 K 与日本中老年女性骨质疏松性骨折风险相关，但与男性无关：村上队列研究
DOI：
10.1017/s0007114520001567
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发表时间：
2020
影响因子：
3.6
通讯作者：
Nakamura Kazutoshi
中科院分区：
文献类型：
--
作者：
Platonova Kseniia;Kitamura Kaori;Watanabe Yumi;Takachi Ribeka;Saito Toshiko;Kabasawa Keiko;Takahashi Akemi;Kobayashi Ryosaku;Oshiki Rieko;Solovev Aleksandr;Iki Masayuki;Tsugane Shoichiro;Sasaki Ayako;Yamazaki Osamu;Watanabe Kei;Nakamura Kazutoshi
尽管膳食钙、维生素 D 和维生素 K 是与骨质疏松症相关的营养因素，但人们对它们对东亚人群骨质疏松性骨折的影响知之甚少。本研究旨在确定这些营养素的摄入是否可以预测骨质疏松性骨折的发生。我们采用了队列研究设计并进行了 5 年的随访。受试者为 12 794 名社区居民（6301 名男性和 6493 名女性），年龄在 40-74 岁之间。通过经过验证的 FFQ 评估膳食中钙、维生素 D 和维生素 K 的摄入量。协变量是人口和生活方式因素。收集所有发生重大骨质疏松性肢体骨折的病例，包括前臂远端、肱骨颈、股骨颈或股骨粗隆、腰椎或胸椎骨折。采用残差法计算能量调整后的钙、维生素 D 和维生素 K 的风险比 (HR)。平均年龄为 58·8 (sd 9·3) 岁。女性钙和维生素 K 的能量调整摄入量较低与总骨折的调整 HR 较高相关（趋势 P 分别 = 0·005 和 0·08）。当椎骨骨折为结果时，Ca 和维生素 K 的 P 趋势值分别为 0·03 和 0·006，最低和最高（参考）摄入组的 HR 分别为 2·03 (95 % CI 1·08、3·82) 和 2·26 (95 % CI 1·19、4·26)。在男性中，骨折事件与三种营养素摄入量之间不存在任何关联。膳食钙和维生素 K 摄入量较低是女性骨质疏松性骨折的独立生活方式相关危险因素，但男性则不然。这些关联对于椎骨骨折来说是强有力的，但对于四肢骨折来说却不是。
Although dietary Ca, vitamin D and vitamin K are nutritional factors associated with osteoporosis, little is known about their effects on incident osteoporotic fractures in East Asian populations. This study aimed to determine whether intakes of these nutrients predict incident osteoporotic fractures. We adopted a cohort study design with a 5-year follow-up. Subjects were 12 794 community-dwelling individuals (6301 men and 6493 women) aged 40–74 years. Dietary intakes of Ca, vitamin D and vitamin K were assessed with a validated FFQ. Covariates were demographic and lifestyle factors. All incident cases of major osteoporotic limb fractures, including those of the distal forearm, neck of humerus, neck or trochanter of femur and lumbar or thoracic spine were collected. Hazard ratios (HR) for energy-adjusted Ca, vitamin D and vitamin K were calculated with the residual method. Mean age was 58·8 (sd 9·3) years. Lower energy-adjusted intakes of Ca and vitamin K in women were associated with higher adjusted HR of total fractures (Pfor trend = 0·005 and 0·08, respectively). When vertebral fracture was the outcome, Pfor trend values for Ca and vitamin K were 0·03 and 0·006, respectively, and HR of the lowest and highest (reference) intake groups were 2·03 (95 % CI 1·08, 3·82) and 2·26 (95 % CI 1·19, 4·26), respectively. In men, there were null associations between incident fractures and each of the three nutrient intakes. Lower intakes of dietary Ca and vitamin K were independent lifestyle-related risk factors for osteoporotic fracture in women but not men. These associations were robust for vertebral fractures, but not for limb fractures.
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影响因子：
4.2
作者：
Ikeda, Y;Iki, M;Yoneshima, H
通讯作者：
Yoneshima, H
营养和生活方式对维生素 D 状态的影响
影响因子：
2.5
作者：
S. Whiting;M. Calvo
通讯作者：
M. Calvo
影响因子：
4.8
作者：
Alhaj, Hamid A.;Massey, Anna E.;McAllister-Williams, R. Hamish
通讯作者：
McAllister-Williams, R. Hamish
日本利用维生素 D 预防肌肉骨骼疾病的村上队列研究
DOI：
--
发表时间：
2015
期刊：
影响因子：
--
作者：
Nakamura K;Kitamura K;Takachi R;Saito T;Kobayashi R;Oshiki R;Watanabe Y
通讯作者：
Watanabe Y
女性维生素 K 摄入量与髋部骨折：一项前瞻性研究。
DOI：
10.1093/ajcn/69.1.74
发表时间：
1999
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Feskanich,D;Weber,P;Willett,WC;Rockett,H;Booth,SL;Colditz,GA
通讯作者：
Colditz,GA