Opioid-related deaths before and after COVID-19 stay-at-home orders in Los Angeles County.
Opioid-related deaths before and after COVID-19 stay-at-home orders in Los Angeles County.
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DOI：
10.1016/j.drugalcdep.2021.109028
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发表时间：
2021-11-01
影响因子：
4.2
通讯作者：
Doctor JN
中科院分区：
文献类型：
--
作者：
Kelley MA;Lucas J;Stewart E;Goldman D;Doctor JN
在新冠肺炎大流行期间，与阿片类药物有关的发病率和死亡率有所增加，但关于受影响最严重的社区的具体信息仍不清楚。我们的目标是评估在洛杉矶县实施家庭主妇命令后，死者水平与阿片类药物相关死亡的相关性。这项回顾性队列研究使用了洛杉矶县验尸官的数据，以确定2019年和2020年与阿片类药物相关的死亡。我们使用Logistic回归分析了在开始在家订购后30天的洗涤期后阿片类药物相关死亡的变化。独立变量包括已故的年龄、性别、种族和民族、死亡时存在的海洛因或芬太尼、人口普查地区的教育，以及死亡前一年的预定药物处方。在洛杉矶县，与阿片类药物相关的死亡在人口普查地区最为常见，那里有一小部分人口拥有学士学位。根据居家订单，在调整了年龄、性别和海洛因或芬太尼的使用后，非西班牙裔高加索人的阿片类药物相关死亡显著高于西班牙人(风险比：1.82[95%CI，1.10-3.02]；P<；0.05)。种族和民族死亡率的差异不能用人口普查、地区一级的教育或最近的预定药物处方来解释。2020年，洛杉矶县与阿片类药物有关的死亡人数出现了令人震惊的上升。在新冠肺炎和相关政策开始实施后，与阿片类药物过量相关的死亡人数增加，最常发生在非西班牙裔高加索人中。需要对这一趋势的根本原因进行进一步研究，以便在这些同时发生的公共卫生危机中提出政策建议。
Opioid-related morbidity and mortality has increased during the COVID-19 pandemic, yet specific information about the communities most affected remains unknown. Our objective is to evaluate decedent-level associations with an opioid-related death following the implementation of stay-at-home orders in Los Angeles County. This retrospective cohort study used data from the L.A. County Medical Examiner-Coroner to identify opioid-related deaths in 2019 and 2020. We used logistic regression to analyze the change in opioid-related deaths following a 30-day washout period after the start of stay-at-home orders. Independent variables included decedent age, gender, race and ethnicity, heroin or fentanyl present at the time of death, census tract-level education, and a scheduled drug prescription in the year before death. Opioid-related deaths in L.A. County are most common in census tracts where a small percentage of the population has a Bachelor’s degree. Following stay-at-home orders, Non-Hispanic Caucasian individuals had significantly more opioid-related deaths than Hispanic individuals (risk ratio (RR): 1.82 [95 % CI, 1.10–3.02]; P < 0.05) after adjusting for age, gender, and heroin or fentanyl use. Racial and ethnic differences in mortality were not explained by census tract-level education or recent scheduled drug prescriptions. There has been an alarming rise in opioid-related deaths in L.A. County during 2020. The increase in opioid-related overdose deaths following the onset of COVID-19 and related policies occurred most often among Non-Hispanic Caucasian individuals. Further research on this trend's underlying cause is needed to inform policy recommendations during these simultaneous public health crises.
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影响因子：
12.7
作者：
Friedman, Joseph;Akre, Samir
通讯作者：
Akre, Samir
影响因子：
13.8
作者：
Appa A;Rodda LN;Cawley C;Zevin B;Coffin PO;Gandhi M;Imbert E
通讯作者：
Imbert E
影响因子：
9.7
作者：
Song, Zirui
通讯作者：
Song, Zirui
DOI：
10.1007/s11524-020-00486-y
发表时间：
2020-12
期刊：
Journal of urban health : bulletin of the New York Academy of Medicine
影响因子：
--
作者：
Rodda LN;West KL;LeSaint KT
通讯作者：
LeSaint KT
影响因子：
4.2
作者：
Slavova, Svetla;Rock, Peter;Walsh, Sharon L.
通讯作者：
Walsh, Sharon L.