Role of stress-related brain-derived neurotrophic factor (BDNF) in the rat submandibular gland.
Role of stress-related brain-derived neurotrophic factor (BDNF) in the rat submandibular gland.
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DOI：
10.1267/ahc.12017
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发表时间：
2012-10-31
影响因子：
2.4
通讯作者：
Saruta J
中科院分区：
文献类型：
--
作者：
Tsukinoki K;Saruta J
神经生长因子（NGF）家族包括NGF、脑源性神经营养因子（BDNF）和神经营养因子(NTs)-3、-4/5、-6和-7，它们统称为神经营养因子。然而，除神经生长因子外，神经营养因子在唾液腺中的表达尚未得到详细描述。通过与TrkB受体的相互作用，BDNF在长时程增强中起重要作用。我们发现BDNF在颌下腺组织中表达增加以应对压力，表明唾液腺对压力敏感。此外，应激导致血浆中源自下颌骨的BDNF和肾上腺髓质中TrkB受体mRNA的增加。急性应激时血浆BDNF可能激活肾上腺髓质中的TrkB受体。唾液腺不仅可能影响口腔健康，还可能影响全身器官。本文综述了激素样作用与大鼠颌下腺应激相关BDNF表达之间的关系。
The nerve growth factor (NGF) family comprises NGF, brain-derived neurotrophic factor (BDNF) and neurotrophins (NTs)-3, -4/5, -6 and -7, all of which are collectively referred to as neurotrophins. However, the expression of neurotrophins other than NGF in the salivary gland has not been described in detail. Through interaction with the TrkB receptor, BDNF plays an important role in long-term potentiation. We found that BDNF expression increased within submandibular gland tissue in response to stress, suggesting that the salivary glands are sensitive to stress. In addition, stress caused increases in plasma BDNF derived from the submandibular gland and in TrkB receptor mRNA in the adrenal medulla. Plasma BDNF might activate TrkB receptors in the adrenal medulla during acute stress. The salivary glands are likely to influence not only oral health, but also systemic organs. This review addressed the relationship between hormone-like effects and stress-related BDNF expression in the rat submandibular gland.
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影响因子：
2.2
作者：
De Vicente, JC;Garcia-Suarez, O;Vega, JA
通讯作者：
Vega, JA
DOI：
10.1002/neu.480251107
发表时间：
1994-11-01
期刊：
JOURNAL OF NEUROBIOLOGY
影响因子：
--
作者：
BARBACID, M
通讯作者：
BARBACID, M
DOI：
10.1073/pnas.83.16.6184
发表时间：
1986-08-01
影响因子：
11.1
作者：
ALOE, L;ALLEVA, E;LEVIMONTALCINI, R
通讯作者：
LEVIMONTALCINI, R
影响因子：
2.4
作者：
Nishida, Tomoki;Arii, Tatsuo;Takaoka, Akio;Yoshimura, Ryoichi;Endo, Yasuhisa
通讯作者：
Endo, Yasuhisa
影响因子：
2.9
作者：
Radka, SF;Holst, PA;Altar, CA
通讯作者：
Altar, CA