Anatomic sites of colonization with community-associated methicillin-resistant Staphylococcus aureus.
Anatomic sites of colonization with community-associated methicillin-resistant Staphylococcus aureus.
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DOI：
10.1086/677627
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发表时间：
2014-09
影响因子：
4.5
通讯作者：
Weinstein RA
中科院分区：
文献类型：
--
作者：
Popovich KJ;Aroutcheva A;Hota B;Beavis KG;Hayden MK;Weinstein RA
耐甲氧西林金黄色葡萄球菌（MRSA）在过去20年中作为社区人群感染的原因出现，所谓的社区相关MRSA（CA-MRSA）。通过脉冲场凝胶电泳（PFGE）分型，USA 300是美国最常见的CA-MRSA菌株。研究表明，CA-MRSA的定植动力学可能与传统MRSA菌株不同，1鼻腔定植可能在CA-MRSA传播和感染中发挥作用。1 USA 300 MRSA菌株的另一个显著特征是与医疗保健相关的MRSA菌株相比，对非b-内酰胺类抗生素的敏感性更高。然而，多药耐药（MDR）USA 300菌株已被描述，主要是在感染人类免疫缺陷病毒（HIV）的患者和男性同性恋（MSM）。2同样值得关注的是，CA-MRSA对常见去殖民化剂（如莫匹罗星2和葡萄糖酸氯己定（CHG）3）的耐药性已被报道。本研究的目的是检查USA 300 MRSA菌株的表型，qacA/B基因在这一人群中的患病率，以及PFGE模式的定殖解剖部位。
Methicillin-resistant Staphylococcus aureus (MRSA) has emerged over the past 20 years as a cause of infections in community populations, so-called community-associated MRSA (CA-MRSA). By pulsed-field gel electrophoresis (PFGE) subtyping, USA300 is the most common CA-MRSA strain in the United States. It has been suggested that the colonization dynamics for CA-MRSA may be different than those for traditional MRSA strains, 1 with extranasal colonization potentially playing a role in CA-MRSA transmission and infection. 1Another distinguishing characteristic of USA300 MRSA strains is greater susceptibility to non-b-lactam antibiotics compared with healthcare-associated MRSA strains. However, multidrug-resistant (MDR) USA300 strains have been described, largely among patients infected with human immunodeficiency virus (HIV) and men who have sex with men (MSM). 2 Also of concern, resistance to common decolonizing agents, such as mupirocin2 and chlorhexidine gluconate (CHG), 3 has been reported in CA-MRSA. The objectives of this study were to examine the phenotype of USA300 MRSA strains, the prevalence of the qacA/B gene in this population, and the anatomic sites of colonization by PFGE pattern.
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影响因子：
39.2
作者：
Diep, Binh An;Chambers, Henry F.;Perdreau-Remington, Francoise
通讯作者：
Perdreau-Remington, Francoise
影响因子：
4.9
作者：
Fritz, Stephanie A.;Hogan, Patrick G.;Burnham, Carey-Ann D.
通讯作者：
Burnham, Carey-Ann D.
影响因子：
11.8
作者：
Popovich, Kyle J.;Hota, Bala;Weinstein, Robert A.
通讯作者：
Weinstein, Robert A.
影响因子：
11.8
作者：
Zanger, Philipp;Nurjadi, Dennis;Kremsner, Peter G.
通讯作者：
Kremsner, Peter G.
影响因子：
9.4
作者：
McDougal, LK;Steward, CD;Tenover, FC
通讯作者：
Tenover, FC