Enamel matrix derivative versus guided tissue regeneration in the presence of nicotine: a histomorphometric study in dogs.
Enamel matrix derivative versus guided tissue regeneration in the presence of nicotine: a histomorphometric study in dogs.
复制标题
牙釉质基质衍生物与尼古丁存在下的引导组织再生：狗的组织形态学研究。
DOI：
10.1111/j.1600-051x.2006.00989.x
复制
发表时间：
2006
影响因子：
6.7
通讯作者：
E. Sallum
中科院分区：
文献类型：
--
作者：
S. Pimentel;A. Sallum;J. B. Saldanha;M. Casati;F. Nociti;E. Sallum
目的
这项组织测量研究的目的是在狗模型中比较在尼古丁的作用下，通过釉基质衍生物（EMD）或引导组织再生（GTR）治疗的开裂型缺陷的愈合过程。
材料和方法
使用了8只杂种犬。颊侧骨性裂开是通过手术在下颌第三和第四前磨牙的近中牙根上造成的。将缺损暴露于斑块累积3个月。在此期间之后，缺损被随机分配到以下治疗之一：开放皮瓣清创术（OFD）、EMD或GTR与可吸收膜。在4个月期间，犬接受尼古丁皮下给药（2 mg/kg，每天两次，两次给药之间间隔12 h）。此后，处死动物并处理组织块。评价的组织学参数包括牙龈退缩、上皮长度、结缔组织适应、新牙骨质和新骨。
结果
EMD组新生牙骨质长度明显优于OFD组（p<0.05）。GTR组与其他组之间无统计学显著差异。
结论
在尼古丁存在下，EMD可能比OFD促进更多的新牙骨质形成，而GTR未能提供显着差异。
AIM
The goal of this histometric study was to compare the healing process of dehiscence-type defects treated by enamel matrix derivative (EMD) or guided tissue regeneration (GTR) under the effect of nicotine in the dog model.
MATERIALS AND METHODS
Eight mongrel dogs were used. Buccal osseous dehiscences were surgically created on the mesial roots of the mandibular third and fourth pre-molars. The defects were exposed to plaque accumulation for 3 months. After this period, the defects were randomly assigned to one of the treatments: open flap debridement (OFD), EMD or GTR with a resorbable membrane. During 4 months, the dogs received subcutaneous administration of nicotine (2 mg/kg twice a day with a 12 h interval between the applications). After this period, the animals were killed and the blocks were processed. The histometric parameters evaluated included gingival recession, epithelial length, connective tissue adaptation, new cementum and new bone.
RESULTS
A superior length of new cementum was observed in the sites treated by EMD in comparison with OFD (p< or =0.05). No statistically significant differences were observed between GTR and the other groups.
CONCLUSIONS
In the presence of nicotine, EMD may promote more new cementum formation than OFD while GTR failed to provide a significant difference.
影响因子：
4.3
作者：
MAGNUSSON, I;BATICH, C;COLLINS, BR
通讯作者：
COLLINS, BR