Emerging rejuvenation strategies-Reducing the biological age.
Emerging rejuvenation strategies-Reducing the biological age.
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新兴的恢复活力策略 - 降低生物年龄。
DOI：
10.1111/acel.13538
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发表时间：
2022-01
期刊：
影响因子：
7.8
通讯作者：
Gladyshev VN
中科院分区：
文献类型：
--
作者：
Zhang B;Trapp A;Kerepesi C;Gladyshev VN
Several interventions have recently emerged that were proposed to reverse rather than just attenuate aging, but the criteria for what it takes to achieve rejuvenation remain controversial. Distinguishing potential rejuvenation therapies from other longevity interventions, such as those that slow down aging, is challenging, and these anti‐aging strategies are often referred to interchangeably. We suggest that the prerequisite for a rejuvenation intervention is a robust, sustained, and systemic reduction in biological age, which can be assessed by biomarkers of aging, such as epigenetic clocks. We discuss known and putative rejuvenation interventions and comparatively analyze them to explore underlying mechanisms. Emerging interventions have suggested that biological aging can be reversed rather than just attenuated, but the criteria for what it takes to achieve rejuvenation remain controversial. In this review, we discuss known and putative rejuvenation interventions, exploring their connections within the context of aging biomarkers. We suggest that the prerequisite for classifying an intervention as rejuvenating is a robust and reproducible reduction in biological age, which can be assessed by high‐dimensional trackers of aging such as epigenetic clocks.
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影响因子：
23.9
作者：
Buganim, Yosef;Markoulaki, Styliani;van Wietmarschen, Niek;Hoke, Heather;Wu, Tao;Ganz, Kibibi;Akhtar-Zaidi, Batool;He, Yupeng;Abraham, Brian J.;Porubsky, David;Kulenkampff, Elisabeth;Faddah, Dina A.;Shi, Linyu;Gao, Qing;Sarkar, Sovan;Cohen, Malkiel;Goldmann, Johanna;Nery, Joseph R.;Schultz, Matthew D.;Ecker, Joseph R.;Xiao, Andrew;Young, Richard A.;Lansdorp, Peter M.;Jaenisch, Rudolf
通讯作者：
Jaenisch, Rudolf
影响因子：
64.8
作者：
Baker DJ;Childs BG;Durik M;Wijers ME;Sieben CJ;Zhong J;Saltness RA;Jeganathan KB;Verzosa GC;Pezeshki A;Khazaie K;Miller JD;van Deursen JM
通讯作者：
van Deursen JM
影响因子：
64.8
作者：
Abad, Maria;Mosteiro, Lluc;Serrano, Manuel
通讯作者：
Serrano, Manuel
影响因子：
5.7
作者：
Breitling LP;Saum KU;Perna L;Schöttker B;Holleczek B;Brenner H
通讯作者：
Brenner H
影响因子：
25
作者：
Gaillard, Afsaneh;Prestoz, Laetitia;Jaber, Mohamed
通讯作者：
Jaber, Mohamed