Association of lipoprotein levels with mortality in subjects aged 50 + without previous diabetes or cardiovascular disease: a population-based register study.
Association of lipoprotein levels with mortality in subjects aged 50 + without previous diabetes or cardiovascular disease: a population-based register study.
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DOI：
10.3109/02813432.2013.824157
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发表时间：
2013-09
影响因子：
2.1
通讯作者：
Nexøe J
中科院分区：
文献类型：
--
作者：
Bathum L;Depont Christensen R;Engers Pedersen L;Lyngsie Pedersen P;Larsen J;Nexøe J
本研究旨在调查基线时没有糖尿病和心血管疾病 (CVD) 的人群中脂蛋白和甘油三酯水平与全因死亡率的关系。欧洲心血管疾病预防指南规定，一般总胆固醇（TC）应< 5 mmol/L（190 mg/dL），低密度脂蛋白胆固醇（LDL-C）应< 3 mmol/L（115 mg/dL）。一项 1999 年至 2007 年期间基于人群的登记研究，包括 118 160 名 50 岁以上受试者，基线时未使用他汀类药物。全因死亡率与脂蛋白和甘油三酯水平相关，并在纳入后根据他汀类药物的使用进行调整。 TC 或 LDL-C 高于推荐水平的组的全因死亡率较低。与 TC < 5 mmol/L 的受试者相比，60-70 岁组的调整后风险比范围为 TC 5-5.99 mmol/L 的 0.68（95% 置信区间 (CI) 0.61-0.77）、TC 6-7.99 mmol/L 的 0.67（95% CI 0.59-0.75）和 1.02（95% CI）。 TC ≥ 8 mmol/L 的男性 CI 为 0.68–1.53)，女性的 CI 为 0.57 (95% CI 0.48–0.67) 至 0.59 (95% CI 0.50–0.68) 和 1.02 (95% CI: 0.77–1.37)。对于甘油三酯，与 60-70 岁女性 < 1 mmol/L 组相比，甘油三酯 1-1.39 的比率范围为 1.04 (95% CI 0.88-1.23) 至 1.35 (95% CI 1.10-1.66) 和 1.25 (95% CI 1.05-1.48)分别为 mmol/L、1.4–1.69 mmol/L 和 ≥ 1.7 mmol/L。纳入后的他汀类药物治疗提供了生存获益。这些关联表明，高脂蛋白水平似乎对普通人群来说并不一定有害。然而，女性的高甘油三酯水平与生存率降低有关。
This study aimed to investigate the association of lipoprotein and triglyceride levels with all-cause mortality in a population free from diabetes and cardiovascular disease (CVD) at baseline. The European Guidelines on cardiovascular disease prevention state that in general total cholesterol (TC) should be < 5 mmol/L (190 mg/dL) and low-density lipoprotein cholesterol (LDL-C) should be < 3 mmol/L (115 mg/dL). A population-based register study in the period 1999–2007 including 118 160 subjects aged 50 + without statin use at baseline. All-cause mortality was related to lipoprotein and triglyceride levels and adjusted for statin use after inclusion. All-cause mortality was lower in the groups with TC or LDL-C above the recommended levels. Compared with subjects with TC < 5 mmol/L, adjusted hazard ratios for the group aged 60–70 years ranged from 0.68 (95% confidence interval (CI) 0.61–0.77) for TC 5–5.99 mmol/L to 0.67 (95% CI 0.59–0.75) for TC 6–7.99 mmol/L and 1.02 (95% CI 0.68–1.53) for TC ≥ 8 mmol/L in males and from 0.57 (95% CI 0.48–0.67) to 0.59 (95% CI 0.50–0.68) and 1.02 (95% CI: 0.77–1.37) in females. For triglycerides, ratios compared with the group < 1 mmol/L in the females aged 60–70 years ranged from 1.04 (95% CI 0.88–1.23) to 1.35 (95% CI 1.10–1.66) and 1.25 (95% CI 1.05–1.48) for triglycerides 1–1.39 mmol/L, 1.4–1.69 mmol/L, and ≥ 1.7 mmol/L, respectively. Statin treatment after inclusion provided a survival benefit. These associations indicate that high lipoprotein levels do not seem to be definitely harmful in the general population. However, high triglyceride levels in females are associated with decreased survival.
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影响因子：
37.8
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