Applications of functionalized fullerenes in tumor theranostics.
Applications of functionalized fullerenes in tumor theranostics.
复制标题
功能化富勒烯在肿瘤治疗学中的应用
作者：
Chen Z;Ma L;Liu Y;Chen C
具有特定物理化学性质的功能化富勒烯已被开发用于癌症诊断和治疗。值得注意的是，金属富勒烯是一种新型的磁共振成像（MRI）对比度增强剂，并可能在临床诊断中有很好的应用前景。多羟基富勒烯和羧基富勒烯已被应用于光声成像。此外，近年来，功能化富勒烯在肿瘤治疗中显示出了潜力，如光动力治疗、光热治疗、放射治疗和化学治疗。它们的抗肿瘤作用可能与氧化应激、抗血管生成和免疫刺激活性的调节有关。虽然各种类型的新型纳米颗粒药物已被用于肿瘤治疗诊断学，但它们在生物体中的分布、代谢和毒性也一直是研究人员关注的问题。本文综述了富勒烯作为肿瘤诊断治疗剂的研究进展，并对其可能的作用机制进行了讨论。
Functionalized fullerenes with specific physicochemical properties have been developed for cancer diagnosis and therapy. Notably, metallofullerene is a new class of magnetic resonance imaging (MRI) contrast-enhancing agent, and may have promising applications for clinical diagnosis. Polyhydroxylated and carboxyl fullerenes have been applied to photoacoustic imaging. Moreover, in recent years, functionalized fullerenes have shown potential in tumor therapies, such as photodynamic therapy, photothermal treatment, radiotherapy and chemotherapeutics. Their antitumor effects may be associated with the modulation of oxidative stress, anti-angiogenesis, and immunostimulatory activity. While various types of novel nanoparticle agents have been exploited in tumor theranostics, their distribution, metabolism and toxicity in organisms have also been a source of concern among researchers. The present review summarizes the potential of fullerenes as tumor theranostics agents and their possible underlying mechanisms are discussed.
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影响因子：
1.5
作者：
Chen, HHC;Yu, C;Chiang, LY
通讯作者：
Chiang, LY
影响因子：
4.1
作者：
Dugan, LL;Lovett, EG;O'Malley, KL
通讯作者：
O'Malley, KL
影响因子：
4.9
作者：
Isobe, Hiroyuki;Nakanishi, Waka;Nakamura, Eiichi
通讯作者：
Nakamura, Eiichi
DOI：
10.1016/j.biocel.2006.05.019
发表时间：
2006-01-01
影响因子：
4
作者：
Alvarez, M. Gabriela;Prucca, Cesar;Rivarola, Viviana
通讯作者：
Rivarola, Viviana
影响因子：
15
作者：
Kato, H;Kanazawa, Y;Shinohara, H
通讯作者：
Shinohara, H