Advances in the polymeric delivery of nucleic acid vaccines.
Advances in the polymeric delivery of nucleic acid vaccines.
复制标题
核酸疫苗聚合递送的进展
DOI：
10.7150/thno.70853
复制
发表时间：
2022
期刊：
影响因子：
12.4
通讯作者：
Zhang, Fuwu
中科院分区：
文献类型：
--
作者：
Chen, Gang;Zhao, Bowen;Ruiz, Elena F.;Zhang, Fuwu
核酸疫苗，特别是信使RNA（mRNA）疫苗，在当前的COVID-19大流行中显示出独特的益处。高分子材料作为传递载体的应用极大地促进了核酸疫苗作为一种有前途的预防和治疗策略。聚合物材料的固有性质使得核酸疫苗具有优异的体内稳定性、增强的生物安全性、特异性细胞摄取、内溶酶体逃逸和促进的抗原表达。尽管核酸疫苗的聚合物递送在过去几十年中取得了显著进展，但聚合物-基因疫苗系统的临床翻译仍然面临着难以克服的挑战。本文综述了用于核酸疫苗递送的各种聚合物及其表征和代表性制剂。并对核酸疫苗和高分子载体应用中存在的问题、应对策略及前景进行了讨论。这篇综述强调了聚合物疫苗递送系统的合理设计和开发，以满足防御严重或新发疾病的目标。
Nucleic acid vaccines, especially messenger RNA (mRNA) vaccines, display unique benefits in the current COVID-19 pandemic. The application of polymeric materials as delivery carriers has greatly promoted nucleic acid vaccine as a promising prophylactic and therapeutic strategy. The inherent properties of polymeric materials render nucleic acid vaccines with excellent in vivo stability, enhanced biosafety, specific cellular uptake, endolysosomal escape, and promoted antigen expression. Although polymeric delivery of nucleic acid vaccines has progressed significantly in the past decades, clinical translation of polymer-gene vaccine systems still faces insurmountable challenges. This review summarizes the diverse polymers and their characterizations and representative formulations for nucleic acid vaccine delivery. We also discussed existing problems, coping strategies, and prospect relevant to applications of nucleic acid vaccines and polymeric carriers. This review highlights the rational design and development of polymeric vaccine delivery systems towards meeting the goals of defending serious or emerging diseases.
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