Maternal Psychiatric Conditions, Treatment With Selective Serotonin Reuptake Inhibitors, and Neurodevelopmental Disorders.
Maternal Psychiatric Conditions, Treatment With Selective Serotonin Reuptake Inhibitors, and Neurodevelopmental Disorders.
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DOI：
10.1016/j.biopsych.2021.04.002
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发表时间：
2021-08-15
影响因子：
10.6
通讯作者：
Croen LA
中科院分区：
文献类型：
--
作者：
Ames JL;Ladd-Acosta C;Fallin MD;Qian Y;Schieve LA;DiGuiseppi C;Lee LC;Kasten EP;Zhou G;Pinto-Martin J;Howerton EM;Eaton CL;Croen LA
本研究旨在阐明孕前和怀孕期间母亲精神疾病和选择性血清素再摄取抑制剂（SSRI）的使用与后代神经发育障碍风险之间的关系。我们使用了“探索早期发展研究”的数据，这是一项在美国针对 2003 年至 2011 年出生的儿童进行的多中心病例对照研究。 ASD（n = 1367）、DD（n = 1750）和一般人群对照（POP）（n = 1671）的最终研究组分类是通过现场标准化发育评估确定的。通过自我报告和医疗记录确定母亲的精神状况和怀孕期间 SSRI 的使用情况。我们使用逻辑回归来评估 ASD 和 DD（相对于 POP）与孕产妇精神状况和妊娠期 SSRI 治疗的关联。为了减少适应症的混淆，我们还在仅限于怀孕期间患有精神疾病的母亲的分析中检查了 SSRI 的关联。与 POP 对照组相比，患有 ASD 或 DD 儿童的母亲在怀孕期间出现精神疾病和使用 SSRI 的情况明显更为常见。怀孕期间未使用 SSRIs 的患有精神疾病的母亲（调整后优势比 (aOR)=1.81，95% 置信区间 (CI) 1.44–2.27）与使用 SSRIs 的母亲（aOR=2.05，95% CI 1.50–2.80）相比，患 ASD 的几率也同样升高。在患有精神疾病的母亲中，SSRI 的使用与后代 ASD 没有显着相关性（aOR=1.14，95% CI 0.8-1.62）。 DD 的主要发现与自闭症谱系障碍 (ASD) 的观察结果表现出相似的关系。母亲的精神疾病与后代神经发育障碍的风险增加相关，但与怀孕期间使用 SSRI 无关。
The present study aims to clarify relationships of maternal psychiatric conditions and selective serotonin reuptake inhibitors (SSRI) use during preconception and pregnancy with risk of neurodevelopmental disorders in offspring. We used data from the Study to Explore Early Development, a multisite case-control study conducted in the United States among children born between 2003–2011. Final study group classifications of ASD (n=1367), DD (n= 1750), and general population controls (POP)(n=1671) were determined by an in-person standardized developmental assessment. Maternal psychiatric conditions and SSRI use during pregnancy were ascertained from both self-report and medical records. We used logistic regression to evaluate associations of ASD and DD (vs. POP) with maternal psychiatric condition and SSRI treatment in pregnancy. To reduce confounding by indication, we also examined SSRI associations in analyses restricted to mothers with psychiatric conditions during pregnancy. Psychiatric conditions and SSRI use during pregnancy were significantly more common among mothers of children with either ASD or DD than POP controls. Odds of ASD were similarly elevated among mothers with psychiatric conditions who did not use SSRIs during pregnancy (adjusted odds ratio (aOR)=1.81, 95% confidence interval (CI) 1.44–2.27) as in mothers who did use SSRIs (aOR=2.05, 95% CI 1.50–2.80). Among mothers with psychiatric conditions, SSRI use was not significantly associated with ASD in offspring (aOR=1.14, 95% CI 0.8–1.62). Primary findings for DD exhibited similar relationships to those observed with ASD. Maternal psychiatric conditions, but not use of SSRIs during pregnancy, were associated with increased risk of neurodevelopmental disorders in offspring.
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影响因子：
12.3
作者：
Carroll LS;Owen MJ
通讯作者：
Owen MJ
影响因子：
2.9
作者：
Alwan, Sura;Reefhuis, Jennita;Friedman, Jan M.
通讯作者：
Friedman, Jan M.
影响因子：
26.1
作者：
Boukhris, Takoua;Sheehy, Odile;Berard, Anick
通讯作者：
Berard, Anick
影响因子：
3.9
作者：
Gidaya, Nicole B.;Lee, Brian K.;Newschaffer, Craig J.
通讯作者：
Newschaffer, Craig J.
DOI：
10.15585/mmwr.ss6706a1
发表时间：
2018-04-27
期刊：
Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. : 2002)
影响因子：
--
作者：
Baio J;Wiggins L;Christensen DL;Maenner MJ;Daniels J;Warren Z;Kurzius-Spencer M;Zahorodny W;Robinson Rosenberg C;White T;Durkin MS;Imm P;Nikolaou L;Yeargin-Allsopp M;Lee LC;Harrington R;Lopez M;Fitzgerald RT;Hewitt A;Pettygrove S;Constantino JN;Vehorn A;Shenouda J;Hall-Lande J;Van Naarden Braun K;Dowling NF
通讯作者：
Dowling NF