Glucose attenuates impairments in memory and CREB activation produced by an α4β2 but not an α7 nicotinic receptor antagonist.
Glucose attenuates impairments in memory and CREB activation produced by an α4β2 but not an α7 nicotinic receptor antagonist.
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DOI：
10.1016/j.neuropharm.2012.11.008
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发表时间：
2013-04
影响因子：
4.7
通讯作者：
Gold PE
中科院分区：
文献类型：
--
作者：
Morris KA;Li S;Bui DD;Gold PE
Glucose improves memory for a variety of tasks when administered to rats and mice near the time of training. Prior work indicates glucose may enhance memory by increasing the synthesis and release of the neurotransmitter acetylcholine in the brain. To investigate if specific acetylcholine receptor subtypes may mediate some of the memory-enhancing actions of glucose, we examined the effects of subtype-specific nicotinic acetylcholine receptor antagonists on memory in Fischer-344 rats and also examined the ability of glucose to reverse drug-induced impairments. Pre-training peripheral injections of methyllycaconitine (MLA) or dihydro-beta-erythroidine (DHβE), which are specific α7 and α4β2 nicotinic receptor antagonists, respectively, dose-dependently impaired retention latencies in an inhibitory avoidance task when tested 7-days but not 1 hour after training. Immediate post-training glucose injections attenuated the impairments, but were more effective in attenuating the DHβE-induced impairments. Likewise, peripheral or direct intrahippocampal injections of MLA or DHβE dosedependently impaired spatial working memory scores on a spontaneous alternation task. Concurrent administration of glucose reversed DHβE- but not MLA-induced impairments. CREB phosphorylation downstream of cholinergic signaling was assessed 30 minutes after spontaneous alternation testing and intrahippocampal drug infusions. Both MLA and DHβE impaired hippocampal CREB phosphorylation; glucose reversed DHβE but not MLA-induced deficits. The effectiveness of glucose in reversing DHβE- but not MLA- induced impairments in behavioral performance and CREB phosphorylation suggests that activation of α7 receptors may play an important role in memory enhancement by glucose.
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影响因子：
16.2
作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
10.1016/s0926-6410(02)00209-4
发表时间：
2003-03-01
期刊：
COGNITIVE BRAIN RESEARCH
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
Cannady, Reginald;Weir, Ruth;Levin, Edward D.
通讯作者：
Levin, Edward D.