California Very Preterm Birth Study: design and characteristics of the population- and biospecimen bank-based nested case-control study.
California Very Preterm Birth Study: design and characteristics of the population- and biospecimen bank-based nested case-control study.
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DOI：
10.1111/j.1365-3016.2011.01252.x
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发表时间：
2012-05
影响因子：
2.8
通讯作者：
Williamson DM
中科院分区：
文献类型：
--
作者：
Kharrazi M;Pearl M;Yang J;DeLorenze GN;Bean CJ;Callaghan WM;Grant A;Lackritz E;Romero R;Satten GA;Simhan H;Torres AR;Westover JB;Yolken R;Williamson DM
在美国，早产是导致婴儿死亡、发病率和种族差异的主要原因。加州的早产研究是为了发现与VPTB相关的母婴遗传和环境因素。本文介绍了研究设计、研究人群、数据和标本收集、实验室方法和研究人群的特征。利用2000年至2007年在南加州五个县出生的活产儿的记录联系建立的大型人口队列，以及全州产前和新生儿筛查的现有数据和库样本，选择了1100例VPTB病例和796对对照母婴进行研究(分别为385/200白人、385/253西班牙裔和330/343黑人病例/对照)。在50多家医院进行了病例的病历摘要，以识别自发性VPTB，提高孕周的准确性，获得相关的临床数据，并排除不符合资格标准的病例。在白人和西班牙裔人中，VPTB被定义为32周出生，在黑人中，VPTB定义为34周出生。大约55%的VPTB是自发的，45%有医学适应症或其他排除。据报道，在自发性室上性早搏中，约有41%患有绒毛膜羊膜炎。虽然加州极早产研究目前的重点是评估候选遗传标记对自发性VPTB的作用，但其设计允许寻求其他研究机会，以确定不同类型VPTB的社会、临床和生物决定因素，最终目的是减少美国和其他地方这些健康结果的婴儿死亡率、发病率和种族差异。
Very preterm birth (VPTB) is a leading cause of infant mortality, morbidity and racial disparity in the U.S. The underlying causes of VPTB are multiple and poorly understood. The California Very Preterm Birth Study was conducted to discover maternal and infant genetic and environmental factors associated with VPTB. This paper describes the study design, population, data and specimen collection, laboratory methods and characteristics of the study population. Using a large, population-based cohort created through record linkage of livebirths delivered from 2000 to 2007 in five counties of southern California, and existing data and banked specimens from state-wide prenatal and newborn screening, 1100 VPTB cases and 796 control mother-infant pairs were selected for study (385/200 White, 385/253 Hispanic and 330/343 Black cases/controls, respectively). Medical record abstraction of cases was conducted at over 50 hospitals to identify spontaneous VPTB, improve accuracy of gestational age, obtain relevant clinical data and exclude cases that did not meet eligibility criteria. VPTB was defined as birth at <32 weeks in Whites and Hispanics and <34 weeks in Blacks. Approximately 55% of all VPTBs were spontaneous and 45% had medical indications or other exclusions. Of the spontaneous VPTBs, approximately 41% were reported to have chorioamnionitis. While the current focus of the California Very Preterm Birth Study is to assess the role of candidate genetic markers on spontaneous VPTB, its design enables the pursuit of other research opportunities to identify social, clinical and biological determinants of different types of VPTB with the ultimate aim of reducing infant mortality, morbidity and racial disparities in these health outcomes in the US and elsewhere.
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影响因子：
8.8
作者：
Bodamer, Olaf A.;Mitterer, Georg;Schmidt, Wolfgang M.
通讯作者：
Schmidt, Wolfgang M.
影响因子：
9.8
作者：
Genç, MR;Gerber, S;Witkin, SS
通讯作者：
Witkin, SS
影响因子：
9.8
作者：
Fortunato, Stephen J.;Menon, Ramkumar;Williams, Scott M.
通讯作者：
Williams, Scott M.
影响因子：
2.1
作者：
Aidoo, M;Mcelroy, PD;Udhayakumar, V
通讯作者：
Udhayakumar, V
影响因子：
5
作者：
Erichsen, HC;Engel, SAM;Chanock, SJ
通讯作者：
Chanock, SJ