Differences in breast cancer risk factors by tumor marker subtypes among premenopausal Vietnamese and Chinese women.
Differences in breast cancer risk factors by tumor marker subtypes among premenopausal Vietnamese and Chinese women.
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越南和中国绝经前女性肿瘤标志物亚型的乳腺癌危险因素差异。
DOI：
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Polly A. Newcomb
中科院分区：
文献类型：
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作者：
H. Nichols;A. Trentham;R. Love;J. Hampton;Pham Thi Hoang Anh;D. Allred;S. Mohsin;Polly A. Newcomb;Polly A. Newcomb
我们在一项病例对照研究中评估了生殖和生活方式风险因素与乳腺癌肿瘤标志物状态之间的关系。病例是生活在越南和中国的绝经前妇女，她们有资格参加卵巢切除术和他莫昔芬作为乳腺癌治疗的临床试验（n = 682）。对照组为年龄与病例相匹配的非亲属医院访客（n = 649）。免疫组化检测雌激素受体（ER）和孕激素受体的存在以及HER-2/neu癌基因的过表达。比值比（OR）和95%置信区间（95% CI）使用无条件逻辑回归进行估计，并根据已知混杂因素进行调整。总的来说，280例（61%）肿瘤样本ER阳性，176例（38%）ER阴性。161例（35%）样品检测到HER-2/neu过表达，286例（26%）样品检测到HER-2/neu阴性。我们观察到胎次增加与乳腺癌风险降低呈负相关趋势（P = 0.002）。与年龄<25岁生育第一胎的女性相比，年龄≥25岁生育第一胎的女性患乳腺癌的风险增加（or, 1.53; 95% CI, 1.20-1.95）。与不饮酒的女性相比，饮酒的女性患乳腺癌的风险增加（OR,1.85; 95% CI, 1.32-2.61）。与对照组相比，经Wald检验，胎次和初产年龄的乳腺癌OR估计值与ER和/或HER-2/新发肿瘤状态显著相关（P < 0.05）。家族史、初潮年龄、累计泌乳、体重指数和受教育程度与乳腺癌风险无显著相关。我们的研究结果支持了一些乳腺癌危险因素因ER和HER-2/新肿瘤标志物亚型而异的假设。
We evaluated associations between reproductive and lifestyle risk factors with breast cancer tumor marker status in a case-control study. Cases were premenopausal women living in Vietnam and China who were eligible for a clinical trial of oophorectomy and tamoxifen as treatment for breast cancer (n = 682). Controls were nonrelative hospital visitors, matched on age to the cases (n = 649). Immunohistochemical analysis was used to identify the presence of estrogen receptor (ER) and progesterone receptor and the overexpression of HER-2/neu oncogene. Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated using unconditional logistic regression, adjusted for known confounders. Overall, 280 (61%) tumor samples were ER positive and 176 (38%) were ER negative. HER-2/neu overexpression was detected in 161 (35%) samples, whereas 286 (26%) samples were HER-2/neu negative. We observed an inverse trend between increasing parity and decreasing breast cancer risk (P = 0.002). Women ages > or =25 years at first birth had increased breast cancer risk compared with women ages <25 years at first birth (OR, 1.53; 95% CI, 1.20-1.95). Women who consumed alcohol had increased risk of breast cancer compared with women who did not (OR,1.85; 95% CI, 1.32-2.61). Compared with controls, OR estimates for breast cancer by parity and age at first birth were significantly associated with ER and/or HER-2/neu tumor status by Wald test (P < 0.05). Family history, age at menarche, cumulative lactation, body mass index, and education were not significantly related to breast cancer risk. Our findings support the hypothesis that some breast cancer risk factors differ by ER and HER-2/neu tumor marker subtypes.
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体型、体力活动和乳腺癌激素受体状态：两项病例对照研究的结果。
DOI：
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发表时间：
2000
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Enger,SM;Ross,RK;Paganini-Hill,A;Carpenter,CL;Bernstein,L
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Bernstein,L
口服避孕药的使用和其他与年轻女性乳腺癌 HER-2/neu 过度表达相关的危险因素。
DOI：
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发表时间：
1999
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
影响因子：
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作者：
Gammon,MD;Hibshoosh,H;Terry,MB;Bose,S;Schoenberg,JB;Brinton,LA;Bernstein,JL;Thompson,WD
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Thompson,WD
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5
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Sellers, TA;Davis, J;Folsom, AR
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Folsom, AR
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8
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R. Pietras;M. Arboleda;Reese Dm;N. Wongvipat;Pegram;Lillian Ramos;C. Gorman;Parker Mg;M. Sliwkowski;D. Slamon
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R. Pietras;M. Arboleda;Reese Dm;N. Wongvipat;Pegram;Lillian Ramos;C. Gorman;Parker Mg;M. Sliwkowski;D. Slamon
DOI：
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发表时间：
1998-05
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
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作者：
K. Egan;M. Stampfer;B. Rosner;D. Trichopoulos;P. A. Newcomb;A. Trentham-Dietz;M. P. Longnecker;R. Mittendorf;E. Greenberg;Walter C. Willett
通讯作者：
K. Egan;M. Stampfer;B. Rosner;D. Trichopoulos;P. A. Newcomb;A. Trentham-Dietz;M. P. Longnecker;R. Mittendorf;E. Greenberg;Walter C. Willett