Risk Factors, Clinical Features, and Polygenic Risk Scores in Schizophrenia and Schizoaffective Disorder Depressive-Type.
Risk Factors, Clinical Features, and Polygenic Risk Scores in Schizophrenia and Schizoaffective Disorder Depressive-Type.
复制标题
精神分裂症和分裂情感性精神障碍抑郁型的危险因素、临床特征和多基因风险评分。
DOI：
10.1093/schbul/sbab036
复制
发表时间：
2021-08-21
影响因子：
6.6
通讯作者：
Walters JTR
中科院分区：
文献类型：
--
作者：
Dennison CA;Legge SE;Hubbard L;Lynham AJ;Zammit S;Holmans P;Cardno AG;Owen MJ;O'Donovan MC;Walters JTR
关于抑郁型情感障碍（SA-D）的地位存在争议，特别是它是否应该被视为精神分裂症的一种形式或一种独特的疾病。我们旨在确定SA-D个体是否与精神分裂症个体在人口统计学、发病前和终生临床特征以及精神分裂症、抑郁症和双相情感障碍的遗传易感性方面存在差异。参与者来自CardiffCOGS样本，符合ICD-10精神分裂症（n = 713）或SA-D（n = 151）标准。两个样本，卡迪夫受影响的同胞（n = 354）和卡迪夫F系列（n = 524），用于复制。对于所有样本，表型数据通过结构化访谈、病历回顾和由训练有素的研究人员进行的ICD-10诊断来确定。采用单变量和多变量logistic回归模型比较精神分裂症和SA-D患者的人口统计学和临床特征以及多基因风险评分（PRS）。在CardiffCOGS中，与精神分裂症相比，SA-D与女性性别、儿童虐待、酒精依赖史、最严重精神病发作时功能性总体评估量表（GAS）评分较高、最严重抑郁症发作时功能性GAS评分较低以及终生严重程度降低有关。混乱症状。与精神分裂症患者相比，SA-D患者有更高的抑郁PRS。精神分裂症和双相情感障碍的PRS在SA-D和精神分裂症之间没有显著差异。与精神分裂症患者相比，SA-D患者有更高的抑郁症的环境和遗传危险因素的发生率，并且与精神分裂症的遗传易感性相似。这些发现与SA-D是精神分裂症的一种亚型是一致的，这是由于精神分裂症和抑郁症的易感性增加所致。
There is controversy about the status of schizoaffective disorder depressive-type (SA-D), particularly whether it should be considered a form of schizophrenia or a distinct disorder. We aimed to determine whether individuals with SA-D differ from individuals with schizophrenia in terms of demographic, premorbid, and lifetime clinical characteristics, and genetic liability to schizophrenia, depression, and bipolar disorder. Participants were from the CardiffCOGS sample and met ICD-10 criteria for schizophrenia (n = 713) or SA-D (n = 151). Two samples, Cardiff Affected-sib (n = 354) and Cardiff F-series (n = 524), were used for replication. For all samples, phenotypic data were ascertained through structured interview, review of medical records, and an ICD-10 diagnosis made by trained researchers. Univariable and multivariable logistic regression models were used to compare individuals with schizophrenia and SA-D for demographic and clinical characteristics, and polygenic risk scores (PRS). In the CardiffCOGS, SA-D, compared to schizophrenia, was associated with female sex, childhood abuse, history of alcohol dependence, higher functioning Global Assessment Scale (GAS) score in worst episode of psychosis, lower functioning GAS score in worst episode of depression, and reduced lifetime severity of disorganized symptoms. Individuals with SA-D had higher depression PRS compared to those with schizophrenia. PRS for schizophrenia and bipolar disorder did not significantly differ between SA-D and schizophrenia. Compared to individuals with schizophrenia, individuals with SA-D had higher rates of environmental and genetic risk factors for depression and a similar genetic liability to schizophrenia. These findings are consistent with SA-D being a sub-type of schizophrenia resulting from elevated liability to both schizophrenia and depression.
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DOI：
10.1093/bioinformatics/btu848
发表时间：
2015-05-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Euesden J;Lewis CM;O'Reilly PF
通讯作者：
O'Reilly PF
影响因子：
9.2
作者：
Chang CC;Chow CC;Tellier LC;Vattikuti S;Purcell SM;Lee JJ
通讯作者：
Lee JJ
影响因子：
6.6
作者：
Craddock, Nick;O'Donovan, M. C.;Owen, M. J.
通讯作者：
Owen, M. J.
影响因子：
6.6
作者：
Maj, M;Pirozzi, R;Bucci, P
通讯作者：
Bucci, P
DOI：
10.1002/ajmg.b.32011
发表时间：
2012-03
影响因子：
2.8
作者：
Cardno, Alastair G.;Rijsdijk, Fruehling V.;West, Robert M.;Gottesman, Irving I.;Craddock, Nick;Murray, Robin M.;McGuffin, Peter
通讯作者：
McGuffin, Peter