A twin study of schizoaffective-mania, schizoaffective-depression, and other psychotic syndromes.
A twin study of schizoaffective-mania, schizoaffective-depression, and other psychotic syndromes.
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DOI：
10.1002/ajmg.b.32011
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发表时间：
2012-03
影响因子：
2.8
通讯作者：
McGuffin, Peter
中科院分区：
文献类型：
--
作者：
Cardno, Alastair G.;Rijsdijk, Fruehling V.;West, Robert M.;Gottesman, Irving I.;Craddock, Nick;Murray, Robin M.;McGuffin, Peter
分裂情感障碍的疾病分类学地位仍然存在争议。双胞胎研究对于调查分裂情感性躁狂、分裂情感性抑郁和其他精神病综合征之间的关系具有潜在价值，但尚未有此类研究的报道。我们从伦敦莫兹利双胞胎登记处（1948-1993）确定了 224 对先证者双胞胎（106 对同卵双胞胎，118 对同性异卵双胞胎），其中先证者有精神病或躁狂症状。我们主要使用非层次分类，此外还使用层次和数据衍生分类，以及一种以广泛的精神分裂症和躁狂综合征为特征的分类，而没有单独的分裂情感综合征。我们调查了评估者间的可靠性以及双胞胎先证者和双胞胎中综合征的共现情况。分裂情感综合征仅显示出中等的评估者间可靠性。在双胞胎先证者和同卵双胞胎中，综合征之间普遍存在显着的共现性，并且分裂情感性躁狂症和躁狂症有最大的共现性趋势。同卵先证者的分裂情感综合征与其双胞胎中发生精神病综合征的风险相对较高相关。没有单独的分裂情感综合征的广泛精神分裂症和躁狂综合征的分类显示出评估者间可靠性的提高，但两种广泛综合征之间具有高度的遗传和环境相关性。结果与分裂情感性躁狂症的观点一致，因为精神分裂症、躁狂症和抑郁症同时发生的可能性较高；精神分裂症和抑郁症的可能性增加，但躁狂症的可能性降低。如果在适当的时候，分裂情感综合征表现出令人满意的评估者间可靠性和一些特定的病因学因素，那么它们也可以被视为部分独立的疾病。
The nosological status of schizoaffective disorders remains controversial. Twin studies are potentially valuable for investigating relationships between schizoaffective-mania, schizoaffective-depression and other psychotic syndromes, but no such study has yet been reported. We ascertained 224 probandwise twin pairs (106 monozygotic, 118 same-sex dizygotic), where probands had psychotic or manic symptoms, from the Maudsley Twin Register in London (1948–1993). We investigated Research Diagnostic Criteria schizoaffective-mania, schizoaffective-depression, schizophrenia, mania and depressive psychosis primarily using a non-hierarchical classification, and additionally using hierarchical and data-derived classifications, and a classification featuring broad schizophrenic and manic syndromes without separate schizoaffective syndromes. We investigated inter-rater reliability and co-occurrence of syndromes within twin probands and twin pairs. The schizoaffective syndromes showed only moderate inter-rater reliability. There was general significant co-occurrence between syndromes within twin probands and monozygotic pairs, and a trend for schizoaffective-mania and mania to have the greatest co-occurrence. Schizoaffective syndromes in monozygotic probands were associated with relatively high risk of a psychotic syndrome occurring in their co-twins. The classification of broad schizophrenic and manic syndromes without separate schizoaffective syndromes showed improved inter-rater reliability, but high genetic and environmental correlations between the two broad syndromes. The results are consistent with regarding schizoaffective-mania as due to co-occurring elevated liability to schizophrenia, mania and depression; and schizoaffective-depression as due to co-occurring elevated liability to schizophrenia and depression, but with less elevation of liability to mania. If in due course schizoaffective syndromes show satisfactory inter-rater reliability and some specific etiological factors they could alternatively be regarded as partly independent disorders.
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DOI：
10.1176/appi.ajp.2010.10030340
发表时间：
2011-01
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Kendler KS;Aggen SH;Knudsen GP;Røysamb E;Neale MC;Reichborn-Kjennerud T
通讯作者：
Reichborn-Kjennerud T
影响因子：
6.6
作者：
Craddock, Nick;O'Donovan, M. C.;Owen, M. J.
通讯作者：
Owen, M. J.
影响因子：
4.4
作者：
Craddock N;Jones I;Kirov G;Jones L
通讯作者：
Jones L
影响因子：
105.7
作者：
Hutcheon, Jennifer A.;Chiolero, Arnaud;Hanley, James A.
通讯作者：
Hanley, James A.
DOI：
10.1007/bf02189965
发表时间：
1993-03-01
影响因子：
4.7
作者：
HILLER, W;DICHTL, G;VONZERSSEN, D
通讯作者：
VONZERSSEN, D