Associations between food-specific IgG antibodies and intestinal permeability biomarkers.
Associations between food-specific IgG antibodies and intestinal permeability biomarkers.
复制标题
食物特异性IgG抗体与肠渗透性生物标志物之间的关联。
DOI：
10.3389/fnut.2022.962093
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发表时间：
2022
影响因子：
5
通讯作者：
Bradley R
中科院分区：
文献类型：
--
作者：
Vita AA;Zwickey H;Bradley R
Increasing translational evidence suggests that intestinal permeability may be a contributing factor to systemic inflammatory events and numerous pathologies. While associations between IgE-mediated food allergies and increased intestinal permeability have been well-characterized, the relationship between IgG-mediated food sensitivities and intestinal permeability is not well-described in the literature. Thus, we tested for associations between intestinal permeability biomarkers and food-specific IgG antibodies in 111 adults, with and without gastrointestinal symptoms. All biomarkers and food-specific IgG antibodies were measured via ELISA. The intestinal permeability biomarkers anti-lipopolysaccharide (LPS) and anti-occludin IgG and IgA antibodies, but not anti-vinculin or anti-CdtB IgG antibodies, were significantly and positively associated with IgG-mediated food sensitivities. These significant relationships were attenuated by adjusting for the severity of wheat, dairy, and egg reactions. The results of this study support strong associations between titers of food-specific IgG antibodies and intestinal permeability biomarkers in adults, to the extent that the presence of multiple IgG antibodies to food, and increasing IgG food titers, can be considered indicative of increased antibodies to LPS and occludin. Notably, neither IgG titers to wheat, eggs, and dairy, nor permeability biomarkers, were increased in symptomatic participants compared to those without symptoms.
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影响因子：
3.7
作者：
Kim KA;Gu W;Lee IA;Joh EH;Kim DH
通讯作者：
Kim DH
影响因子：
7.7
作者：
Fukao S;Haniuda K;Tamaki H;Kitamura D
通讯作者：
Kitamura D
影响因子：
3.9
作者：
Ostrowska L;Wasiluk D;Lieners CFJ;Gałęcka M;Bartnicka A;Tveiten D
通讯作者：
Tveiten D
肠易激综合症（IBS）的个性化，不受限制的热量饮食（IBS），食物特异性血清IgG和症状减轻。
影响因子：
4.5
作者：
Cappelletti M;Tognon E;Vona L;Basello K;Costanzi A;Speciani MC;Speciani AF
通讯作者：
Speciani AF
影响因子：
7.1
作者：
McDonald, Christine M.;Manji, Karim P.;Duggan, Christopher P.
通讯作者：
Duggan, Christopher P.