Mining the Mesenchymal Stromal Cell Secretome in Patients with Chronic Left Ventricular Dysfunction.
Mining the Mesenchymal Stromal Cell Secretome in Patients with Chronic Left Ventricular Dysfunction.
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慢性左心室功能障碍患者间充质间质细胞分泌组的研究。
作者：
对心血管细胞疗法临床试验初步结果的仔细检查表明，患者特异性差异对结果的重要性以及优化或定制细胞疗法的必要性。再生医学和细胞疗法的领域已经从使用异质性骨髓单核细胞（BMMNC）过渡到间充质基质细胞（MSC），其被认为通过旁分泌活性引起益处。在这里，我们检查了来自参加FOSSIL-CCTRN试验的心力衰竭患者的BMMNC的MSC。我们试图确定心脏功能改善和下降的患者之间MSC的差异，无论接受何种治疗。虽然我们没有观察到各组间MSC细胞谱的差异，但我们确实发现MSC分泌组谱在改善或下降的患者之间存在显著差异。我们的结论是，“挖掘”MSC分泌组可能提供线索，以更好地了解患者特征对细胞治疗后结果的影响，这方面的知识可以为未来的细胞治疗试验提供信息。
Close examination of the initial results of cardiovascular cell therapy clinical trials indicates the importance of patient-specific differences on outcomes and the need to optimize or customize cell therapies. The fields of regenerative medicine and cell therapy have transitioned from using heterogeneous bone marrow mononuclear cells (BMMNCs) to mesenchymal stromal cells (MSCs), which are believed to elicit benefits through paracrine activity. Here, we examined MSCs from the BMMNCs of heart failure patients enrolled in the FOCUS-CCTRN trial. We sought to identify differences in MSCs between patients who improved and those who declined in heart function, regardless of treatment received. Although we did not observe differences in the cell profile of MSCs between groups, we did find significant differences in the MSC secretome profile between patients who improved or declined. We conclude that “mining” the MSC secretome may provide clues to better understand the impact of patient characteristics on outcomes after cell therapy and this knowledge can inform future cell therapy trials.
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与慢性左心室功能障碍患者功能改善相关的外周血生物标志物：FOCUS-CCTRN 试验的生物样本库评估。
影响因子：
3.6
作者：
Chacon Alberty L;Perin EC;Willerson JT;Gahremanpour A;Bolli R;Yang PC;Traverse JH;Lai D;Pepine CJ;Taylor DA
通讯作者：
Taylor DA
外泌体 MicroRNA-21 驱动的人子宫内膜间充质干细胞增强心脏保护作用
影响因子：
6
作者：
Wang K;Jiang Z;Webster KA;Chen J;Hu H;Zhou Y;Zhao J;Wang L;Wang Y;Zhong Z;Ni C;Li Q;Xiang C;Zhang L;Wu R;Zhu W;Yu H;Hu X;Wang J
通讯作者：
Wang J
影响因子：
24
作者：
Zhang, Jianyi;Bolli, Roberto;Garry, Daniel J.;Marban, Eduardo;Menasche, Philippe;Zimmermann, Wolfram-Hubertus;Kamp, Timothy J.;Wu, Joseph C.;Dzau, Victor J.
通讯作者：
Dzau, Victor J.
影响因子：
5.5
作者：
Liu C;Han D;Liang P;Li Y;Cao F
通讯作者：
Cao F
影响因子：
20.1
作者：
Agarwal U;George A;Bhutani S;Ghosh-Choudhary S;Maxwell JT;Brown ME;Mehta Y;Platt MO;Liang Y;Sahoo S;Davis ME
通讯作者：
Davis ME