Renal erythropoietin-producing cells in health and disease.
Renal erythropoietin-producing cells in health and disease.
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DOI：
10.3389/fphys.2015.00167
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发表时间：
2015
影响因子：
4
通讯作者：
Yamamoto M
中科院分区：
文献类型：
--
作者：
Souma T;Suzuki N;Yamamoto M
促红细胞生成素（Epo）是一种重要的促红细胞生成激素，主要由肾Epo生成细胞（REPs）产生。EPO的产生在REP中以低氧诱导的方式受到严格调节，以维持组织氧稳态。REP产生的Epo不足导致肾性贫血和与慢性疾病相关的贫血。最近的研究拓宽了我们对REP的理解，从原型缺氧反应细胞到动态纤维化细胞。在慢性肾脏疾病中，REP是瘢痕形成肌成纤维细胞的主要来源，并积极产生纤维化分子，包括炎性细胞因子。值得注意的是，成肌纤维细胞转化的REP（MF-REP）在疾病损伤消退后恢复其原始生理特性，表明肾性贫血和纤维化在一定程度上是可逆的。因此，了解REPs的可塑性将导致开发新的肾纤维化和贫血的靶向治疗药物。本文综述了低氧诱导Epo基因表达的调控机制。
Erythropoietin (Epo) is an indispensable erythropoietic hormone primarily produced from renal Epo-producing cells (REPs). Epo production in REPs is tightly regulated in a hypoxia-inducible manner to maintain tissue oxygen homeostasis. Insufficient Epo production by REPs causes renal anemia and anemia associated with chronic disorders. Recent studies have broadened our understanding of REPs from prototypic hypoxia-responsive cells to dynamic fibrogenic cells. In chronic kidney disease, REPs are the major source of scar-forming myofibroblasts and actively produce fibrogenic molecules, including inflammatory cytokines. Notably, myofibroblast-transformed REPs (MF-REPs) recover their original physiological properties after resolution of the disease insults, suggesting that renal anemia and fibrosis could be reversible to some extent. Therefore, understanding the plasticity of REPs will lead to the development of novel targeted therapeutics for both renal fibrosis and anemia. This review summarizes the regulatory mechanisms how hypoxia-inducible Epo gene expression is attained in health and disease conditions.
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影响因子：
64.8
作者：
JACOBS, K;SHOEMAKER, C;MIYAKE, T
通讯作者：
MIYAKE, T
影响因子：
19.6
作者：
通讯作者：
--
影响因子：
5.4
作者：
Bunn, H. Franklin
通讯作者：
Bunn, H. Franklin
影响因子：
82.9
作者：
通讯作者：
--
DOI：
10.1073/pnas.84.22.7972
发表时间：
1987-11-01
影响因子：
11.1
作者：
GOLDBERG, MA;GLASS, GA;BUNN, HF
通讯作者：
BUNN, HF