Comparison of pneumatic nebulization and hydride generation inductively coupled plasma mass spectrometry for isotopic analysis of selenium.
Comparison of pneumatic nebulization and hydride generation inductively coupled plasma mass spectrometry for isotopic analysis of selenium.
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气动雾化和氢化物发生电感耦合等离子体质谱法用于硒同位素分析的比较。
DOI：
10.1021/ac00182a013
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发表时间：
1989
影响因子：
7.4
通讯作者：
Ting,BT
中科院分区：
文献类型：
--
作者：
Janghorbani,M;Ting,BT
对气动雾化和连续氢化物发生作为电感耦合等离子体质谱进样方法进行了比较研究，用于人体代谢研究中生物样品中硒的同位素分析。对影响系统分析性能的实验参数进行了评估：仪器操作参数、分析物溶质/NaBH4流速和NaBH4浓度。对三个稳定同位素T4Se、77Se和“Se的SignaMo背景比进行了考察。虽然氢化物体系的本底计数率比雾化方法大3-5倍，但氢化物体系的本底比(按Se浓度归一化)要大30-50倍。两种体系的绝对检出限分别为20-60(雾化)和0.6-1.8 ng(氢化物)。对氢化物体系的整体记忆进行了评估。只有当分析顺序从高到低(偏差1-4%)时，从切换到不同同位素组成的分析液，在40000万S内观察到了可测量的效果。然而，如果层序是从低比到高比，则可以在一个数量级或更高的同位素比范围内获得精确和线性的校准曲线。虽然进一步的改进可能导致灵敏度和精密度的潜在提高，高达一个数量级，但氢化物系统目前的性能对于使用74Se作为体内稳定同位素示踪剂的代谢研究的同位素分析的要求是令人满意的。
A comparative Investigation between pneumatic nebulization and continuous hydride generation as sample Introduction methods for Inductively coupled plasma mass spectrometry was carried out for Isotopic analysis of selenium In biological samples of Interest to human metabolic studies. Experimental parameters known to affect the analytical performance of the system were evaluated: Instrument operating parameters, analyte solutlon/NaBH4 flow rate, and NaBH4 concentration. SignaMo-background ratio was examined for the three stable Isotopes T4Se, 77Se, and “Se. While background count rates for the hydride system were 3-5 times larger than those for the nebulization method, the slgnal-to-background ratios, normalized for Se concentration, were 30-50 times greater for the hydride system. Absolute detection limits (3< r) for the two systems were 20-60 (nebulzatlon) and 0.6-1.8 (hydride) ng of Se. Overall memory of the hydride system was evaluated. Measurable effects were observed within 400 s from switching to analyte solution with differing Isotopic composition, only If the sequence of analysis was from high to low ratio (1-4% bias). However, If the sequence was from low to high ratio, precise and linear calibration plots could be obtained over the Isotope ratio range of an order of magnitude or higher. While further Improvements might lead to potential enhancement of sensitivity and precision of as much as an order of magnitude, the present performance of the hydride system was satisfactory In relation to the requirements of isotopic analysis for metabolic Investigations employing 74Se as the In vivo stable Isotope tracer.
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通过电感耦合等离子体质谱法准确测量锂的稳定同位素。
DOI：
--
发表时间：
1987
期刊：
In Analysis
影响因子：
--
作者：
X. F. Sun;B. Ting;S. Zeisel;M. Janghorbani
通讯作者：
M. Janghorbani
ICP-MS 在人体代谢研究中准确同位素分析的应用
DOI：
--
发表时间：
1987
期刊：
影响因子：
--
作者：
B. Ting;M. Janghorbani
通讯作者：
M. Janghorbani
通过电感耦合等离子体/质谱法测定同位素比，用于锌生物利用度研究
DOI：
--
发表时间：
1986
期刊：
影响因子：
--
作者：
R. E. Serfass;Joseph J. Thompson;R. Houk
通讯作者：
R. Houk
氢化物发生-直流等离子体-原子发射光谱法测定环境样品中的砷和硒
DOI：
--
发表时间：
1987
期刊：
影响因子：
--
作者：
L. Ebdon;S. Sparkes
通讯作者：
S. Sparkes
电感耦合等离子体质谱中等离子体操作参数对分析物信号的影响
DOI：
--
发表时间：
1985
期刊：
影响因子：
--
作者：
G. Horlick;S. Tan;M. Vaughan;C. Rose
通讯作者：
C. Rose