Novel Model for Cascading Failure Based on Degree Strength and Its Application in Directed Gene Logic Networks.
Novel Model for Cascading Failure Based on Degree Strength and Its Application in Directed Gene Logic Networks.
复制标题
基于度强度的级联故障模型及其在有向基因逻辑网络中的应用
DOI：
10.1155/2018/8950794
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发表时间：
2018
影响因子：
--
通讯作者：
Lv K
中科院分区：
文献类型：
--
作者：
Zhang Y;Zhao M;Su J;Lu X;Lv K
提出了一种基于节点度强度的有向逻辑网络连锁故障模型。对节点的入度和出度强度的定义进行了重新考虑，提出了非孤立节点处的荷载为节点的入度强度与出度强度之比。将基于度强度的级联失效模型应用于肺腺癌、前列腺癌和结肠癌3种癌症的逻辑网络中，并根据其基因表达谱进行分析。为了突出三种网络之间的级联故障机制的差异，我们使用最大规模的级联和累积级联概率来描述的损害。研究发现，由枢纽节点引起的连锁故障通常较大。此外，结果表明，网络的传播与连接的逻辑偶的结构模体相关。最后，根据连锁故障机理选择了部分基因。我们认为这些基因可能参与了三种癌症的发生和发展。
A novel model for cascading failures in a directed logic network based on the degree strength at a node was proposed. The definitions of in-degree and out-degree strength of a node were initially reconsidered, and the load at a nonisolated node was proposed as the ratio of in-degree strength to out-degree strength of the node. The cascading failure model based on degree strength was applied to the logic network for three types of cancer including adenocarcinoma of lung, prostate cancer, and colon cancer based on their gene expression profiles. In order to highlight the differences between the three networks by the cascading failure mechanism, we used the largest-scale cascades and the cumulative cascade probability to depict the damage. It was found that the cascading failures caused by hubs are usually larger. Furthermore, the result shows that propagations against the networks were correlated with the structures motifs of connected logical doublets. Finally, some genes were selected based on cascading failure mechanism. We believe that these genes may be involved in the occurrence and development of three types of cancer.
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影响因子：
4.3
作者：
Samuels, Y;Velculescu, VE
通讯作者：
Velculescu, VE
影响因子：
2.4
作者：
Motter, AE;Lai, YC
通讯作者：
Lai, YC
影响因子：
6.1
作者：
Wang, Jian-Wei;Rong, Li-Li
通讯作者：
Rong, Li-Li
基于逻辑关系的基因网络分析
影响因子：
2.1
作者：
Wang, Shudong;Chen, Yan;Meng, Dazhi
通讯作者：
Meng, Dazhi
影响因子：
56.9
作者：
Bowers, PM;Cokus, SJ;Yeates, TO
通讯作者：
Yeates, TO