Viral carcinogenesis: factors inducing DNA damage and virus integration.
Viral carcinogenesis: factors inducing DNA damage and virus integration.
复制标题
DOI：
10.3390/cancers6042155
复制
发表时间：
2014-10-22
期刊：
影响因子：
5.2
通讯作者：
Duerksen-Hughes P
中科院分区：
文献类型：
--
作者：
Chen Y;Williams V;Filippova M;Filippov V;Duerksen-Hughes P
病毒是全世界10%-15%人类癌症的病原体。病毒诱导的重编程最常见的结果是基因组不稳定性，包括突变、畸变和DNA损伤的积累。虽然每种病毒都有其促进致癌的特定机制，但大多数DNA致癌病毒编码的致癌基因通常通过靶向p53和pRB转化感染的细胞。此外，病毒DNA整合到人类基因组中也可以在促进包括HBV和HPV在内的几种病毒的肿瘤发展中发挥重要作用。由于病毒整合需要病毒和宿主DNA的断裂，因此认为整合率与DNA损伤水平有关。DNA损伤可由内源性和外源性因素引起，包括由病毒本身或与其他因子、环境因子和其他因素的共感染诱导的炎症。通常，癌症在最初感染后数年至数十年发展。更好地了解病毒介导的致癌作用，参与转化的途径网络和相关的风险因素，特别是在那些通过病毒整合进行肿瘤发生的情况下，将有助于提出预防和治疗策略，以减少病毒介导的癌症的风险。
Viruses are the causative agents of 10%–15% of human cancers worldwide. The most common outcome for virus-induced reprogramming is genomic instability, including accumulation of mutations, aberrations and DNA damage. Although each virus has its own specific mechanism for promoting carcinogenesis, the majority of DNA oncogenic viruses encode oncogenes that transform infected cells, frequently by targeting p53 and pRB. In addition, integration of viral DNA into the human genome can also play an important role in promoting tumor development for several viruses, including HBV and HPV. Because viral integration requires the breakage of both the viral and the host DNA, the integration rate is believed to be linked to the levels of DNA damage. DNA damage can be caused by both endogenous and exogenous factors, including inflammation induced by either the virus itself or by co-infections with other agents, environmental agents and other factors. Typically, cancer develops years to decades following the initial infection. A better understanding of virus-mediated carcinogenesis, the networking of pathways involved in transformation and the relevant risk factors, particularly in those cases where tumorigenesis proceeds by way of virus integration, will help to suggest prophylactic and therapeutic strategies to reduce the risk of virus-mediated cancer.
登录
查看更多内容
影响因子：
11.4
作者：
BOSHART, M;GISSMANN, L;HAUSEN, HZ
通讯作者：
HAUSEN, HZ
DOI：
10.1001/jama.1965.03080070025007
发表时间：
1965-01-01
影响因子：
--
作者：
BLUMBERG, BS;ALTER, HJ;VISNICH, S
通讯作者：
VISNICH, S
DOI：
10.1073/pnas.211026798
发表时间：
2001-10-09
影响因子：
11.1
作者：
Cacciotti, P;Libener, R;Gaudino, G
通讯作者：
Gaudino, G
DOI：
10.1073/pnas.85.5.1539
发表时间：
1988-03-01
影响因子：
11.1
作者：
BRAUN, L;MEAD, JE;FAUSTO, N
通讯作者：
FAUSTO, N
影响因子：
8.8
作者：
Autier, P;Coibion, M;Grivegnee, AR
通讯作者：
Grivegnee, AR