Esophageal cancer male to female incidence ratios in Africa: A systematic review and meta-analysis of geographic, time and age trends.
Esophageal cancer male to female incidence ratios in Africa: A systematic review and meta-analysis of geographic, time and age trends.
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DOI：
10.1016/j.canep.2018.01.020
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发表时间：
2018-04
影响因子：
2.6
通讯作者：
McCormack VA
中科院分区：
文献类型：
--
作者：
Middleton DRS;Bouaoun L;Hanisch R;Bray F;Dzamalala C;Chasimpha S;Menya D;Mbalawa CG;N'Da G;Woldegeorgis MA;Njie R;Koulibaly M;Buziba N;Ferro J;Nouhou H;Ogunbiyi F;Wabinga HR;Chokunonga E;Borok MZ;Korir AR;Mwasamwaja AO;Mmbaga BT;Schüz J;McCormack VA
我们使用来自36个国家197个人群的数据对非洲大陆食管癌性别比例进行了回顾和荟萃分析。我们观察到，在总体和高风险的东部和南部非洲地区，男性的发病率一直高于男性。在高风险的东部和南部非洲区域，30-39奥尔兹的男子明显过多。我们的研究结果表明，非洲EC负担的很大一部分可以通过针对性别的暴露来避免。食管鳞状细胞癌（ESCC）仍然是许多转型国家食管癌（EC）的主要组织学亚型，其病因不明且地理位置独特，在许多东部和南部非洲国家的发病率持续升高。为了获得对整个非洲大陆ESCC模式的流行病学见解，我们根据地理位置，时间和诊断年龄对非洲EC年龄标准化（世界）发病率的男女（M：F）性别比进行了系统回顾和荟萃分析。来自36个国家的197个人群的数据被纳入分析，这些数据来自IARC的五大洲癌症发病率，非洲癌症和撒哈拉以南非洲癌症报告中的癌症登记处，以及同行评议文献的系统搜索。观察到男性发病率总体（1.7; 95% CI：1.4，2.0）、高风险东部（1.6; 95% CI：1.4，1.8）和南部（1.8; 95% CI：1.5，2.0）非洲地区持续偏高。在后两个区域，30-39奥尔兹的男子明显过多，而在低风险区域没有观察到这种情况。尽管可能的转诊偏见影响的M：F比的解释性的地方和时间，ESCC发病率的高度异质性意味着很大一部分的疾病是可以预防的，并指导研究调查，以阐明在非洲的年轻男性的早期暴露。
We conducted a review and meta-analysis of esophageal cancer sex ratios in mainland Africa using data from 197 populations in 36 countries. We observed a consistent male excess in incidence rates overall and in the high-risk Eastern and Southern African regions. A male excess was evident in 30–39 year olds in high-risk Eastern and Southern African regions. Our findings suggest that a substantial fraction of the African EC burden could be avoided by targeting gender-specific exposures. Esophageal squamous cell carcinoma (ESCC) remains the predominant histological subtype of esophageal cancer (EC) in many transitioning countries, with an enigmatic and geographically distinct etiology, and consistently elevated incidence rates in many Eastern and Southern African countries. To gain epidemiological insights into ESCC patterns across the continent, we conducted a systematic review and meta-analysis of male-to-female (M:F) sex ratios of EC age-standardised (world) incidence rates in Africa according to geography, time and age at diagnosis. Data from 197 populations in 36 countries were included in the analysis, based on data from cancer registries included in IARC’s Cancer Incidence in Five Continents, Cancer in Africa and Cancer in Sub-Saharan Africa reports, alongside a systematic search of peer-reviewed literature. A consistent male excess in incidence rates overall (1.7; 95% CI: 1.4, 2.0), and in the high-risk Eastern (1.6; 95% CI: 1.4, 1.8) and Southern (1.8; 95% CI: 1.5, 2.0) African regions was observed. Within the latter two regions, there was a male excess evident in 30–39 year olds that was not observed in low-risk regions. Despite possible referral biases affecting the interpretability of the M:F ratios in place and time, the high degree of heterogeneity in ESCC incidence implies a large fraction of the disease is preventable, and directs research enquiries to elucidate early-age exposures among young men in Africa.
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DOI：
10.4102/phcfm.v5i1.471
发表时间：
2013-08-13
影响因子：
2
作者：
Chirowa F;Atwood S;Van der Putten M
通讯作者：
Van der Putten M
影响因子：
2.2
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影响因子：
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Ibanez-Gonzalez, Daniel Lopes;Norris, Shane A.
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Norris, Shane A.
影响因子：
4.3
作者：
Asombang, Akwi W.;Kayamba, Violet;Kelly, Paul
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Kelly, Paul