Type I interferons in infectious disease.
Type I interferons in infectious disease.
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DOI：
10.1038/nri3787
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发表时间：
2015-03
期刊：
影响因子：
--
通讯作者：
O'Garra A
中科院分区：
文献类型：
--
作者：
McNab F;Mayer-Barber K;Sher A;Wack A;O'Garra A
I型干扰素（IFN）在病毒、细菌、寄生虫和真菌感染期间直接和/或通过诱导其他介质对先天性和适应性免疫细胞具有不同的作用。I型IFN对于宿主防御病毒是重要的。然而，最近，它们已被证明在一些急性病毒感染中引起免疫病理学，例如流感病毒，并且相反地，它们可以在慢性病毒感染期间导致免疫抑制，例如淋巴细胞性脉络丛脑膜炎病毒。在细菌感染期间，可能需要早期和低水平的I型IFN来启动细胞介导的免疫应答。高浓度的I型IFN可能阻断B细胞应答或导致免疫抑制分子的产生，并且还降低巨噬细胞对IFNγ活化的应答性，如单核细胞增生李斯特菌和结核分枝杆菌感染所示。最近在结核病实验模型中的研究表明，前列腺素E2和白细胞介素-1抑制I型IFN的表达和下游效应，证明了在感染性疾病期间起作用的细胞因子的交叉调节网络以最小的宿主损伤提供保护。
Type I interferons (IFNs) have diverse effects on innate and adaptive immune cells during infection with viruses, bacteria, parasites and fungi, directly and/or through the induction of other mediators. Type I IFNs are important for host defence against viruses. However, more recently, they have been shown to cause immune pathology in some acute viral infections, such as influenza virus, and, conversely, they can lead to immune suppression during chronic viral infections, such as lymphocytic choriomeningitis virus. During bacterial infections, type I IFNs may be required early and at low levels to initiate cell-mediated immune responses. High concentrations of type I IFNs may block B cell responses or lead to the production of immunosuppressive molecules and also reduce the responsiveness of macrophages to activation by IFNγ, as shown for infections with Listeria monocytogenes and Mycobacterium tuberculosis. Recent studies in experimental models of tuberculosis have demonstrated that prostaglandin E2 and interleukin-1 inhibit type I IFN expression and the downstream effects, demonstrating the cross-regulatory network of cytokines that operates during infectious diseases to provide protection with minimum host damage.
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影响因子：
64.8
作者：
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影响因子：
5.4
作者：
Chi, Bo;Dickensheets, Harold L.;Rabin, Ronald L.
通讯作者：
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DOI：
10.1126/science.1224026
发表时间：
2012-09-28
期刊：
Science (New York, N.Y.)
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4.4
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作者：
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