Bioinspired, vertically stacked, and perovskite nanocrystal-enhanced CMOS imaging sensors for resolving UV spectral signatures.
Bioinspired, vertically stacked, and perovskite nanocrystal-enhanced CMOS imaging sensors for resolving UV spectral signatures.
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DOI：
10.1126/sciadv.adk3860
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发表时间：
2023-11-03
期刊：
影响因子：
13.6
通讯作者：
Gruev, Viktor
中科院分区：
文献类型：
--
作者：
Chen, Cheng;Wang, Ziwen;Wu, Jiajing;Deng, Zhengtao;Zhang, Tao;Zhu, Zhongmin;Jin, Yifei;Lew, Benjamin;Srivastava, Indrajit;Liang, Zuodong;Nie, Shuming;Gruev, Viktor
成像和识别紫外线(UV)光谱中的目标特征和生物医学标记对于医学成像、军事目标跟踪、遥感和工业自动化具有广泛的重要意义。然而，由于紫外光的快速吸收和衰减，目前的硅基成像传感器从根本上是有限的，这阻碍了它们解析紫外光谱特征的能力。在这里，我们提出了一种生物灵感成像传感器，能够在紫外光范围内进行波长分辨成像。受凤蝶对紫外线敏感的视觉系统的启发，该传感器将垂直堆叠的光电二极管和钙钛矿纳米晶体单片结合在一起。这种成像设计结合了两种互补的紫外光检测机制：纳米晶层将一部分紫外光信号转换为可见荧光，由光电二极管阵列检测，而剩余的紫外光由顶部的光电二极管检测。我们的芳香族氨基酸和肿瘤/正常细胞的无标记紫外荧光成像数据使这些生物医学材料的实时区分具有99%的可信度。采用钙钛矿型纳米晶体、灵感来自蝴蝶的Papilio xutus相机能够通过UV自体荧光识别癌细胞。
Imaging and identifying target signatures and biomedical markers in the ultraviolet (UV) spectrum is broadly important to medical imaging, military target tracking, remote sensing, and industrial automation. However, current silicon-based imaging sensors are fundamentally limited because of the rapid absorption and attenuation of UV light, hindering their ability to resolve UV spectral signatures. Here, we present a bioinspired imaging sensor capable of wavelength-resolved imaging in the UV range. Inspired by the UV-sensitive visual system of the Papilio xuthus butterfly, the sensor monolithically combines vertically stacked photodiodes and perovskite nanocrystals. This imaging design combines two complementary UV detection mechanisms: The nanocrystal layer converts a portion of UV signals into visible fluorescence, detected by the photodiode array, while the remaining UV light is detected by the top photodiode. Our label-free UV fluorescence imaging data from aromatic amino acids and cancer/normal cells enables real-time differentiation of these biomedical materials with 99% confidence. Papilio xuthus butterfly–inspired camera with perovskite nanocrystals enables cancer cell identification via UV autofluorescence.
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影响因子：
17.1
作者：
Dey A;Ye J;De A;Debroye E;Ha SK;Bladt E;Kshirsagar AS;Wang Z;Yin J;Wang Y;Quan LN;Yan F;Gao M;Li X;Shamsi J;Debnath T;Cao M;Scheel MA;Kumar S;Steele JA;Gerhard M;Chouhan L;Xu K;Wu XG;Li Y;Zhang Y;Dutta A;Han C;Vincon I;Rogach AL;Nag A;Samanta A;Korgel BA;Shih CJ;Gamelin DR;Son DH;Zeng H;Zhong H;Sun H;Demir HV;Scheblykin IG;Mora-Seró I;Stolarczyk JK;Zhang JZ;Feldmann J;Hofkens J;Luther JM;Pérez-Prieto J;Li L;Manna L;Bodnarchuk MI;Kovalenko MV;Roeffaers MBJ;Pradhan N;Mohammed OF;Bakr OM;Yang P;Müller-Buschbaum P;Kamat PV;Bao Q;Zhang Q;Krahne R;Galian RE;Stranks SD;Bals S;Biju V;Tisdale WA;Yan Y;Hoye RLZ;Polavarapu L
通讯作者：
Polavarapu L
影响因子：
64.8
作者：
Perry M;Kinoshita M;Saldi G;Huo L;Arikawa K;Desplan C
通讯作者：
Desplan C
DOI：
10.1002/advs.201700335
发表时间：
2017-11
期刊：
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
影响因子：
--
作者：
Liu M;Zhong G;Yin Y;Miao J;Li K;Wang C;Xu X;Shen C;Meng H
通讯作者：
Meng H
影响因子：
3.5
作者：
Banerjee, Bhaskar;Renkoski, Timothy;Utzinger, Urs
通讯作者：
Utzinger, Urs
影响因子：
4.9
作者：
Ramasamy, Parthiban;Lim, Da-Hye;Lee, Jong-Soo
通讯作者：
Lee, Jong-Soo