Transformation stimulates glucose transporter gene expression in the absence of protein kinase C.
Transformation stimulates glucose transporter gene expression in the absence of protein kinase C.
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在蛋白激酶 C 缺失的情况下，转化可刺激葡萄糖转运蛋白基因表达。
DOI：
10.1073/pnas.86.21.8252
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发表时间：
1989
影响因子：
11.1
通讯作者：
Birnbaum,MJ
中科院分区：
文献类型：
--
作者：
Hiraki,Y;GarciadeHerreros,A;Birnbaum,MJ
大鼠脑葡萄糖转运蛋白（GT）基因被迅速激活，与肿瘤转化或生长因子对静止成纤维细胞的作用相一致。后者的反应已被证明是介导的蛋白激酶C依赖性和非依赖性途径。我们研究了蛋白激酶C在转化诱导的GT基因激活中的作用。转化成纤维细胞的v-fps或Ki-ras癌基因迅速增加GT mRNA的水平。任一病毒癌基因仍然能够刺激GT基因耗尽后的细胞蛋白激酶C的成纤维细胞与佛波醇12-肉豆蔻酸酯13-乙酸酯的长时间预处理。这些数据表明，蛋白激酶C是不需要的基因转录的致癌转化的快速激活。
The rat brain glucose transporter (GT) gene is rapidly activated coincident with the initiation of growth in response to oncogenic transformation or the addition of growth factors to quiescent fibroblasts. The latter response has been shown to be mediated by protein kinase C-dependent and-independent pathways. We studied the role of protein kinase C in the transformation-induced activation of the GT gene. Transformation of fibroblasts by either the v-fps or the Ki-ras oncogene rapidly increased the levels of GT mRNA. Either viral oncogene remained capable of stimulating the GT gene after depletion of cellular protein kinase C by prolonged pretreatment of fibroblasts with phorbol 12-myristate 13-acetate. These data indicate that protein kinase C is not required for the rapid activation of gene transcription by oncogenic transformation.
影响因子：
4.3
作者：
H. Sambrook
通讯作者：
H. Sambrook
功能性蛋白激酶 C 参与 H-ras 癌基因产物的有丝分裂反应
影响因子：
5.3
作者：
J. Lacal;Timothy P. Fleming;Barbour S. Warren;Peter M. Blumberg;STUART A. Aaronson
通讯作者：
STUART A. Aaronson