Comparison of the reliability and validity of outcome instruments for cutaneous dermatomyositis.
Comparison of the reliability and validity of outcome instruments for cutaneous dermatomyositis.
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DOI：
10.1111/j.1365-2133.2008.08711.x
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发表时间：
2008-09
期刊：
影响因子：
--
通讯作者：
Werth VP
中科院分区：
文献类型：
--
作者：
Klein RQ;Bangert CA;Costner M;Connolly MK;Tanikawa A;Okawa J;Rose M;Fakharzadeh SS;Fiorentino D;Lee LA;Sontheimer RD;Taylor L;Troxel AB;Werth VP
皮肤皮肌炎（DM）需要可靠和有效的皮肤疾病严重程度的措施。CDASI（皮肤皮肌炎疾病面积和严重程度指数）、DSSI（皮肌炎皮肤严重程度指数）和CAT（皮肤评估工具）皮肤指数已被开发为结果工具。我们试图证明这些工具用于测量疾病严重程度的可靠性和有效性。CDASI有4个活动和2个损害指标，评分从0到148。DSSI根据体表面积和严重程度在0至72的量表上评估活动。CAT使用21个活动和伤害项目，活动范围为0到175，伤害范围为0到33。10名皮肤科医生在一次会议上使用这些仪器对12至16名相同的患者进行评分。对医生和患者实施了全球验证措施。总体验证指标与3种结局工具相关（p<0.0001）。相对于CDASI，CAT显示出较低的评分者间和评分者内可靠性。所有量表与医生的相关性均优于与患者的整体皮肤测量值的相关性。CDASI可能是皮肤DM研究的一个有用的结局指标。有必要进一步测试，以比较所有三种措施的反应。
Reliable and validated measures of skin disease severity are needed for cutaneous dermatomyositis (DM). CDASI (Cutaneous Dermatomyositis Disease Area and Severity Index), DSSI (Dermatomyositis Skin Severity Index), and CAT (Cutaneous Assessment Tool) skin indices have been developed as outcome instruments. We sought to demonstrate reliability and validity of these tools for use in measuring disease severity. CDASI has 4 activity and 2 damage measures, with scores from 0 to 148. DSSI assesses activity based on body surface area and severity on a scale of 0 to 72. CAT uses 21 activity and damage items, for a range of 0 to 175 for activity and 0 to 33 for damage. Ten dermatologists used the instruments to score the same 12 to 16 patients in one session. Global validation measures were administered to physicians and patients. Global validation measures correlated with the 3 outcome instruments (p<0.0001). CAT displayed lower inter- and intra-rater reliability relative to the CDASI. All scales correlate better with physician than patient global skin measures. It appears that the CDASI may be a useful outcome measure for studies of cutaneous DM. Further testing to compare responsiveness of all three measures is necessary.
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DOI：
10.1002/art.23340
发表时间：
2008-02-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Huber, Adam M.;Dugan, Elizabeth M.;Rider, Lisa G.
通讯作者：
Rider, Lisa G.
影响因子：
6
作者：
Downing, SM
通讯作者：
Downing, SM
影响因子：
6.5
作者：
Albrecht, J;Taylor, L;Werth, VP
通讯作者：
Werth, VP
影响因子：
1.9
作者：
LANDIS, JR;KOCH, GG
通讯作者：
KOCH, GG
影响因子：
2.6
作者：
Corzillius, M;Fortin, P;Stucki, G
通讯作者：
Stucki, G