3D MRI-based anisotropic FSI models with cyclic bending for human coronary atherosclerotic plaque mechanical analysis.
3D MRI-based anisotropic FSI models with cyclic bending for human coronary atherosclerotic plaque mechanical analysis.
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DOI：
10.1115/1.3127253
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发表时间：
2009-06
期刊：
影响因子：
--
通讯作者：
Ku DN
中科院分区：
文献类型：
--
作者：
Tang D;Yang C;Kobayashi S;Zheng J;Woodard PK;Teng Z;Billiar K;Bach R;Ku DN
心脏病发作和中风通常是由动脉粥样硬化斑块破裂引起的，大多数情况下都没有警告。基于MRI的动脉粥样硬化斑块模型与流体-结构相互作用（FSI）已被引入执行流量和应力/应变分析，并确定可能的机械和形态指标，准确的斑块脆弱性评估。对于冠状动脉，与心脏运动和血管壁的各向异性相关的周期性弯曲可能对斑块中的流动和应力/应变分布具有显著影响。目前的文献中缺乏具有循环弯曲和各向异性血管特性的冠状动脉斑块FSI模型。在本文中，循环弯曲和各向异性血管属性被添加到3D FSI冠状动脉斑块模型，使模型将更加逼真，更准确的计算流量和应力/应变预测。使用一个离体MRI人冠状动脉斑块样本数据构建了六个计算模型，以评估循环弯曲、各向异性血管特性、脉动压力、斑块结构和轴向拉伸对斑块应力/应变分布的影响。我们的研究结果表明，循环弯曲和各向异性性能可能会导致50%-800%的最大主应力（应力-P1）值在选定的位置增加。应力增加随位置而变化，并且当弯曲与轴向拉伸、非光滑斑块结构和共振压力条件（零相位角偏移）耦合时更高。循环弯曲对流动行为的影响更为温和（最大速度降低9.8%，流量降低2.5%，最大流动剪切应力增加15%）。包括循环弯曲，各向异性血管材料的属性，准确的斑块结构，和轴向拉伸计算FSI模型应导致相当大的提高冠状动脉斑块易损性评估的计算应力/应变预测的准确性。需要进一步的研究，包括额外的机械性能数据和体内MRI数据，以获得更完整和准确的知识，在冠状动脉斑块的流动和应力/应变行为，并确定更好的斑块评估和可能的破裂预测的关键指标。
Heart attack and stroke are often caused by atherosclerotic plaque rupture which happens without warning most of the time. MRI-based atherosclerotic plaque models with fluid-structure interactions (FSI) have been introduced to perform flow and stress/strain analysis and identify possible mechanical and morphological indices for accurate plaque vulnerability assessment. For coronary arteries, cyclic bending associated with heart motion and anisotropy of the vessel walls may have significant influence on flow and stress/strain distributions in the plaque. FSI models with cyclic bending and anisotropic vessel properties for coronary plaques are lacking in the current literature. In this paper, cyclic bending and anisotropic vessel properties were added to 3D FSI coronary plaque models so that the models would be more realistic for more accurate computational flow and stress/strain predictions. Six computational models using one ex vivo MRI human coronary plaque specimen data were constructed to assess the effects of cyclic bending, anisotropic vessel properties, pulsating pressure, plaque structure, and axial stretch on plaque stress/strain distributions. Our results indicate that cyclic bending and anisotropic properties may cause 50%–800% increase in maximum principal stress (Stress-P1) values at selected locations. The stress increase varies with location and is higher when bending is coupled with axial stretch, non-smooth plaque structure, and resonant pressure conditions (zero phase angle shift). Effects of cyclic bending on flow behaviors are more modest (9.8% decrease in maximum velocity, 2.5% decrease in flow rate, 15% increase in maximum flow shear stress). Inclusion of cyclic bending, anisotropic vessel material properties, accurate plaque structure, and axial stretch in computational FSI models should lead to considerable improvement of accuracy of computational stress/strain predictions for coronary plaque vulnerability assessment. Further studies incorporating additional mechanical property data and in vivo MRI data are needed to obtain more complete and accurate knowledge about flow and stress/strain behaviors in coronary plaques and to identify critical indicators for better plaque assessment and possible rupture predictions.
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发表时间：
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影响因子：
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