Regulatory Effect of General Anesthetics on Activity of Potassium Channels.
Regulatory Effect of General Anesthetics on Activity of Potassium Channels.
复制标题
全身麻醉药对钾通道活性的调节作用
DOI：
10.1007/s12264-018-0239-1
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发表时间：
2018-10
影响因子：
5.6
通讯作者：
Zhang Z
中科院分区：
文献类型：
--
作者：
Li Y;Xu J;Xu Y;Zhao XY;Liu Y;Wang J;Wang GM;Lv YT;Tang QY;Zhang Z
General anesthesia is an unconscious state induced by anesthetics for surgery. The molecular targets and cellular mechanisms of general anesthetics in the mammalian nervous system have been investigated during past decades. In recent years, K+channels have been identified as important targets of both volatile and intravenous anesthetics. This review covers achievements that have been made both on the regulatory effect of general anesthetics on the activity of K+channels and their underlying mechanisms. Advances in research on the modulation of K+channels by general anesthetics are summarized and categorized according to four large K+channel families based on their amino-acid sequence homology. In addition, research achievements on the roles of K+channels in general anesthesiain vivo, especially with regard to studies using mice with K+channel knockout, are particularly emphasized.
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影响因子：
3.3
作者：
Aller, M. I.;Wisden, W.
通讯作者：
Wisden, W.
DOI：
10.1152/ajpcell.1998.275.4.c1009
发表时间：
1998-10-01
影响因子：
5.5
作者：
Correa, AM
通讯作者：
Correa, AM
影响因子：
3.6
作者：
Gruss, M;Bushell, TJ;Franks, NP
通讯作者：
Franks, NP
影响因子：
64.8
作者：
Cirelli, C;Bushey, D;Tononi, G
通讯作者：
Tononi, G
影响因子：
5.7
作者：
Gerstin, KM;Gong, DH;Gray, AT
通讯作者：
Gray, AT