Mammalian gut metabolomes mirror microbiome composition and host phylogeny.
Mammalian gut metabolomes mirror microbiome composition and host phylogeny.
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DOI：
10.1038/s41396-021-01152-0
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发表时间：
2022-05
期刊：
影响因子：
11
通讯作者：
Mizrahi, Itzhak
中科院分区：
文献类型：
--
作者：
Gregor, Rachel;Probst, Maraike;Eyal, Stav;Aksenov, Alexander;Sasson, Goor;Horovitz, Igal;Dorrestein, Pieter C.;Meijler, Michael M.;Mizrahi, Itzhak
在过去的十年中，对哺乳动物肠道微生物组的研究表明，不同的动物物种具有不同的肠道微生物组成。微生物组成的这种变化的功能后果仍然不清楚：这些分类学差异是否表明微生物适应宿主特异性功能，或者这些不同的微生物群落基本上是功能冗余的，如以前的宏基因组学研究所示？在这里，我们研究了哺乳动物肠道微生物组的代谢内容作为生态系统功能的直接窗口，使用非靶向代谢组学平台与动物学中心合作分析了来自25种外来哺乳动物物种的101份粪便样本。我们发现，哺乳动物的代谢组是化学多样性和强烈的微生物组的组成，和代谢组的组成进一步相关的哺乳动物宿主的生殖。在不同动物物种中富集的特定代谢物包括改性和降解的宿主和膳食化合物，如胆汁酸和三萜类化合物，以及发酵产物，如乳酸和短链脂肪酸。我们的研究结果表明，微生物分类组成的差异确实转化为宿主特异性代谢，这表明分类上遥远的微生物组在功能上更加多样化而不是冗余。
In the past decade, studies on the mammalian gut microbiome have revealed that different animal species have distinct gut microbial compositions. The functional ramifications of this variation in microbial composition remain unclear: do these taxonomic differences indicate microbial adaptations to host-specific functionality, or are these diverse microbial communities essentially functionally redundant, as has been indicated by previous metagenomics studies? Here, we examine the metabolic content of mammalian gut microbiomes as a direct window into ecosystem function, using an untargeted metabolomics platform to analyze 101 fecal samples from a range of 25 exotic mammalian species in collaboration with a zoological center. We find that mammalian metabolomes are chemically diverse and strongly linked to microbiome composition, and that metabolome composition is further correlated to the phylogeny of the mammalian host. Specific metabolites enriched in different animal species included modified and degraded host and dietary compounds such as bile acids and triterpenoids, as well as fermentation products such as lactate and short-chain fatty acids. Our results suggest that differences in microbial taxonomic composition are indeed translated to host-specific metabolism, indicating that taxonomically distant microbiomes are more functionally diverse than redundant.
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影响因子：
4.3
作者：
da Silva RR;Wang M;Nothias LF;van der Hooft JJJ;Caraballo-Rodríguez AM;Fox E;Balunas MJ;Klassen JL;Lopes NP;Dorrestein PC
通讯作者：
Dorrestein PC
影响因子：
9.8
作者：
Brooks AW;Kohl KD;Brucker RM;van Opstal EJ;Bordenstein SR
通讯作者：
Bordenstein SR
DOI：
10.1038/ismej.2012.8
发表时间：
2012-08
期刊：
The ISME journal
影响因子：
--
作者：
通讯作者：
--
影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
影响因子：
46.9
作者：
Aksenov AA;Laponogov I;Zhang Z;Doran SLF;Belluomo I;Veselkov D;Bittremieux W;Nothias LF;Nothias-Esposito M;Maloney KN;Misra BB;Melnik AV;Smirnov A;Du X;Jones KL 2nd;Dorrestein K;Panitchpakdi M;Ernst M;van der Hooft JJJ;Gonzalez M;Carazzone C;Amézquita A;Callewaert C;Morton JT;Quinn RA;Bouslimani A;Orio AA;Petras D;Smania AM;Couvillion SP;Burnet MC;Nicora CD;Zink E;Metz TO;Artaev V;Humston-Fulmer E;Gregor R;Meijler MM;Mizrahi I;Eyal S;Anderson B;Dutton R;Lugan R;Boulch PL;Guitton Y;Prevost S;Poirier A;Dervilly G;Le Bizec B;Fait A;Persi NS;Song C;Gashu K;Coras R;Guma M;Manasson J;Scher JU;Barupal DK;Alseekh S;Fernie AR;Mirnezami R;Vasiliou V;Schmid R;Borisov RS;Kulikova LN;Knight R;Wang M;Hanna GB;Dorrestein PC;Veselkov K
通讯作者：
Veselkov K