Low-density lipoprotein electronegativity is a novel cardiometabolic risk factor.
Low-density lipoprotein electronegativity is a novel cardiometabolic risk factor.
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DOI：
10.1371/journal.pone.0107340
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Chen CH
中科院分区：
文献类型：
--
作者：
Hsu JF;Chou TC;Lu J;Chen SH;Chen FY;Chen CC;Chen JL;Elayda M;Ballantyne CM;Shayani S;Chen CH
低密度脂蛋白(LDL)在心血管疾病(CVD)的发生发展中起着核心作用。在根据电荷进行层析分解的低密度脂蛋白中，电负性最强的亚组分-L5-是唯一能在培养的血管细胞中诱导动脉粥样硬化反应的亚组分。此外，越来越多的证据表明，在心血管高危人群中，血浆L5水平升高。我们假设低密度脂蛋白电负性是一种预测心血管疾病的新指标。在30名无症状的代谢综合征(METS)患者和27名健康对照受试者中，我们根据Framingham风险评分，检验了血浆L5水平与符合METS标准的数量、心血管危险因素和心血管风险之间的相关性。METS组L5水平显著高于对照组(21.9±18.7 mg/dL比11.2±10.7 mg/dL，P<0.01)。琼克希尔趋势检验显示，L5占总低密度脂蛋白的百分比(L5%)和L5浓度随着蛋氨酸标准的增加而增加(P<；0.001)。15%与经典的心血管疾病危险因素相关，包括腰围、体重指数、腰围/身高比、吸烟状况、血压以及空腹血糖、甘油三酯和高密度脂蛋白水平。逐步回归分析显示，空腹血糖水平和体重指数对15%变异的贡献率为28%。L5浓度与CVD风险相关，在控制腰围变化时，L5浓度对30年总体CVD风险方差的贡献率为11%。我们的研究结果表明，低密度脂蛋白电负性与多种心血管危险因素和心血管疾病风险相关，提示低密度脂蛋白电负性指数有可能成为预测心血管疾病的新指标。有必要进行大规模临床试验，以检验这一假设的可靠性和低密度脂蛋白电负性指数的临床重要性。
Low-density lipoprotein (LDL) plays a central role in cardiovascular disease (CVD) development. In LDL chromatographically resolved according to charge, the most electronegative subfraction–L5–is the only subfraction that induces atherogenic responses in cultured vascular cells. Furthermore, increasing evidence has shown that plasma L5 levels are elevated in individuals with high cardiovascular risk. We hypothesized that LDL electronegativity is a novel index for predicting CVD. In 30 asymptomatic individuals with metabolic syndrome (MetS) and 27 healthy control subjects, we examined correlations between plasma L5 levels and the number of MetS criteria fulfilled, CVD risk factors, and CVD risk according to the Framingham risk score. L5 levels were significantly higher in MetS subjects than in control subjects (21.9±18.7 mg/dL vs. 11.2±10.7 mg/dL, P:0.01). The Jonckheere trend test revealed that the percent L5 of total LDL (L5%) and L5 concentration increased with the number of MetS criteria (P<0.001). L5% correlated with classic CVD risk factors, including waist circumference, body mass index, waist-to-height ratio, smoking status, blood pressure, and levels of fasting plasma glucose, triglyceride, and high-density lipoprotein. Stepwise regression analysis revealed that fasting plasma glucose level and body mass index contributed to 28% of L5% variance. The L5 concentration was associated with CVD risk and contributed to 11% of 30-year general CVD risk variance when controlling the variance of waist circumference. Our findings show that LDL electronegativity was associated with multiple CVD risk factors and CVD risk, suggesting that the LDL electronegativity index may have the potential to be a novel index for predicting CVD. Large-scale clinical trials are warranted to test the reliability of this hypothesis and the clinical importance of the LDL electronegativity index.
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影响因子：
3.7
作者：
Chu CS;Wang YC;Lu LS;Walton B;Yilmaz HR;Huang RY;Sawamura T;Dixon RA;Lai WT;Chen CH;Lu J
通讯作者：
Lu J
影响因子：
37.8
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20.3
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8.7
作者：
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通讯作者：
Moatti, N