Novel routes for metabolism of 7-ketocholesterol.
Novel routes for metabolism of 7-ketocholesterol.
复制标题
7-酮胆固醇代谢的新途径。
DOI：
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发表时间：
2005
影响因子：
2.6
通讯作者：
Andrew J. Brown
中科院分区：
文献类型：
--
作者：
W. Jessup;Andrew J. Brown
Oxysterols (oxygenated forms of cholesterol) are present at low levels in the circulation and accumulate is plasma and tissues in some pathologies. In atherosclerotic lesions, 7-oxygenated oxysterols, predominantly 7-ketocholesterol, accumulate and have been implicated in the pathology of the disease. Therefore, knowledge of the mechanisms for 7-ketocholesterol generation and metabolism may provide therapeutic drug targets. There is some in vivo and in vitro evidence that sterol 27-hydroxylase acts on 7-ketocholesterol to initiate its degradation to more polar, water-soluble products. Recent studies indicate an alternative mechanism, in which 7-ketocholesterol is reduced to 7 beta-hydroxycholesterol by 11 beta-hydroxysteroid dehydrogenase type 1.
甾醇 27-羟化酶缺陷型小鼠中 7-酮胆固醇肝脏代谢的反常增强。
DOI：
10.1016/s1388-1981(02)00156-7
发表时间：
2002
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Lyons,MalcolmA;Maeda,Nobuyo;Brown,AndrewJ
通讯作者：
Brown,AndrewJ
糖皮质激素抑制脱氢表雄酮 7-羟基和 7-氧代代谢物的相互转化：11β-羟基类固醇脱氢酶的作用？
影响因子：
3.9
作者：
Robinzon,Boaz;Michael,KristyK;Ripp,SharonL;Winters,StephenJ;Prough,RussellA
通讯作者：
Prough,RussellA