Peripheral inflammation is associated with altered substantia nigra activity and psychomotor slowing in humans.
Peripheral inflammation is associated with altered substantia nigra activity and psychomotor slowing in humans.
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DOI：
10.1016/j.biopsych.2007.12.007
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发表时间：
2008-06-01
影响因子：
10.6
通讯作者：
Critchley HD
中科院分区：
文献类型：
--
作者：
Brydon L;Harrison NA;Walker C;Steptoe A;Critchley HD
全身感染通常会引起包括精神发育迟滞在内的疾病症状。在先天免疫应答期间释放的炎性细胞因子涉及外周炎性信号到大脑的通信。我们使用功能性磁共振脑成像（fMRI）研究了16名健康男性接种伤寒疫苗后外周炎症的神经效应，采用双盲、随机、交叉对照设计。接种疫苗对神经血管偶联没有全局影响，但在低水平视觉刺激期间显著干扰黑质内的神经反应。在认知任务中，伤寒疫苗接种产生更高水平的循环白细胞介素-6的个人有显着较慢的反应时间反应。延长的反应时间和更大的白细胞介素-6反应与黑质内诱发的神经活动有关。我们的研究结果为炎症和神经认知性能之间的相互作用提供了机制性的见解，特别是涉及循环细胞因子和中脑多巴胺能核介导全身感染的精神后果。
Systemic infections commonly cause sickness symptoms including psychomotor retardation. Inflammatory cytokines released during the innate immune response are implicated in the communication of peripheral inflammatory signals to the brain. We used functional magnetic resonance brain imaging (fMRI) to investigate neural effects of peripheral inflammation following typhoid vaccination in 16 healthy men, using a double-blind, randomized, crossover-controlled design. Vaccination had no global effect on neurovascular coupling but markedly perturbed neural reactivity within substantia nigra during low-level visual stimulation. During a cognitive task, individuals in whom typhoid vaccination engendered higher levels of circulating interleukin-6 had significantly slower reaction time responses. Prolonged reaction times and larger interleukin-6 responses were associated with evoked neural activity within substantia nigra. Our findings provide mechanistic insights into the interaction between inflammation and neurocognitive performance, specifically implicating circulating cytokines and midbrain dopaminergic nuclei in mediating the psychomotor consequences of systemic infection.
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