Prospects for Therapies in Osteoarthritis.
Prospects for Therapies in Osteoarthritis.
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DOI:
10.1007/s00223-020-00672-9
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发表时间:
2021-09
影响因子:
4.2
通讯作者:
Conaghan PG
中科院分区:
文献类型:
--
作者:
Ghouri A;Conaghan PG
Osteoarthritis (OA) is a chronic, debilitating disease affecting millions of people worldwide. Management of OA involves pharmacological and non-pharmacological approaches. Conventional pharmacological treatments have limited efficacy and are associated with a number of side-effects, restricting the number of patients who can use them. New pharmacological therapies for managing OA are required and a number have been developed targeting different tissues in OA: bone and cartilage, synovium and nerves. However, there has been overall limited success. Disease-modifying osteoarthritis drugs (DMOADs) are a putative class of therapies aimed at improving OA structural pathologies and consequent symptoms. Recent DMOAD studies have demonstrated some promising therapies but also provided new considerations for future trials.
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