Prospects for Therapies in Osteoarthritis.

Prospects for Therapies in Osteoarthritis.
复制标题

DOI:
10.1007/s00223-020-00672-9
复制
发表时间:
2021-09
影响因子:
4.2
通讯作者:
Conaghan PG
Conaghan PG
中科院分区:
医学3区
文献类型:
--
作者:
Ghouri A;Conaghan PG

文献摘要

参考文献

被引文献

相似文献

骨关节炎(OA)是一种慢性、使人衰弱的疾病,影响着全世界数百万人。OA的管理涉及药物和非药物方法。传统的药物治疗效果有限,并且与许多副作用有关,限制了可以使用它们的患者数量。需要用于管理OA的新药物疗法,并且已经开发了许多针对OA中不同组织的药物疗法:骨和软骨、滑膜和神经。然而,总体上取得的成功有限。疾病缓解骨关节炎药物(DMOAD)是一种公认的旨在改善OA结构病理和后续症状的治疗方法。最近的DMOAD研究已经证明了一些有前途的治疗方法,但也为未来的试验提供了新的考虑。
Osteoarthritis (OA) is a chronic, debilitating disease affecting millions of people worldwide. Management of OA involves pharmacological and non-pharmacological approaches. Conventional pharmacological treatments have limited efficacy and are associated with a number of side-effects, restricting the number of patients who can use them. New pharmacological therapies for managing OA are required and a number have been developed targeting different tissues in OA: bone and cartilage, synovium and nerves. However, there has been overall limited success. Disease-modifying osteoarthritis drugs (DMOADs) are a putative class of therapies aimed at improving OA structural pathologies and consequent symptoms. Recent DMOAD studies have demonstrated some promising therapies but also provided new considerations for future trials.
DOI: 10.1016/j.joca.2017.08.015
发表时间: 2018-01-01
影响因子: 7
作者:
Deshmukh, V.;Hu, H.;Yazici, Y.
通讯作者: Yazici, Y.
DOI: 10.1110/ps.035402.108
发表时间: 2008-08-01
期刊: PROTEIN SCIENCE
影响因子: 8
作者:
Abdiche, Yasmina Noubia;Malashock, Dan Stephen;Pons, Jaume
通讯作者: Pons, Jaume
DOI: 10.1038/boneres.2016.44
发表时间: 2017
期刊: Bone research
影响因子: 12.7
作者:
Chen D;Shen J;Zhao W;Wang T;Han L;Hamilton JL;Im HJ
通讯作者: Im HJ
DOI: 10.1016/j.cyto.2014.10.023
发表时间: 2015-02-01
期刊: CYTOKINE
影响因子: 3.8
作者:
Cheleschi, Sara;Cantarini, Luca;Fioravanti, Antonella
通讯作者: Fioravanti, Antonella
DOI: 10.1016/j.joca.2004.09.001
发表时间: 2004-12-01
影响因子: 7
作者:
Blumenkrantz, G;Lindsey, CT;Majumdar, S
通讯作者: Majumdar, S