What is the biological significance of BDNF mRNA targeting in the dendrites?
What is the biological significance of BDNF mRNA targeting in the dendrites?
复制标题
BDNF mRNA 靶向树突的生物学意义是什么？
作者：
E. Tongiorgi;L. Domenici;M. Simonato
脑源性神经营养因子（BDNF）是神经细胞生物学的几个部分相反的方面的调节因子，包括存活，生长，分化和细胞死亡。调节BDNF在不同亚细胞结构域如细胞索马、树突、轴突和棘的局部可用性似乎是赋予这种神经营养因子引起的不同效应的空间和时间特异性的关键。本文综述了最近的研究结果的背景下，癫痫和视皮层成熟，表明不同的BDNF信使RNA（mRNA）转录本定位于不同的亚细胞位置在海马和皮层神经元。它还审查了研究结果表明，强去极化刺激，在体外和体内，引起BDNF的mRNA和蛋白质的积累在远端树突通过一个信号通路，涉及激活的N-甲基-d-天冬氨酸和酪氨酸激酶B受体和细胞内的Ca 2+浓度的增加。最后，本文提出，BDNF mRNA和蛋白质的不同亚细胞结构域，特别是树突状区室的交付的调节可能代表了癫痫发生和出生后的视觉皮层发育的基础细胞和突触形态重排的过程的一个基本方面。
The neurotrophin brain-derived neurotrophic factor (BDNF) is a regulatory factor of several, partially contrasting, aspects of the biology of neural cells, including survival, growth, differentiation, and cell death. Regulation of the local availability of BDNF at distinct subcellular domains such as the cell soma, dendrites, axons, and spines appears to be the key to conferring spatial and temporal specificity of the different effects elicited by this neurotrophin. This article reviews recent findings in the context of epileptogenesis and visual cortex maturation that showed that different BDNF messenger RNA (mRNA) transcripts are localized at different subcellular locations in hippocampal and cortical neurons. It also reviews findings demonstrating that strong depolarizing stimuli, both in vitro and in vivo, elicit accumulation of BDNF mRNA and protein in the distal dendrites through a signaling pathway involving the activation of the N-methyl-d-aspartate and tyrosine kinase B receptors and an intracellular increase in Ca2+ concentration. Finally, this article proposes that the regulation of the delivery of BDNF mRNA and protein to the different subcellular domains—particularly the dendritic compartment—may represent a fundamental aspect of the processes of cellular and synaptic morphological rearrangements underlying epileptogenesis and postnatal development of the visual cortex.
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DOI：
10.1073/pnas.90.19.8802
发表时间：
1993-10-01
影响因子：
11.1
作者：
METSIS, M;TIMMUSK, T;PERSSON, H
通讯作者：
PERSSON, H
影响因子：
2.5
作者：
H. Scharfman
通讯作者：
H. Scharfman
DOI：
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发表时间：
--
期刊：
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影响因子：
--
作者：
通讯作者：
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DOI：
10.1073/pnas.95.17.10235
发表时间：
1998-08-18
影响因子：
11.1
作者：
Levine, ES;Crozier, RA;Plummer, MR
通讯作者：
Plummer, MR
影响因子：
2.5
作者：
Frerking, M;Malenka, RC;Nicoll, RA
通讯作者：
Nicoll, RA