CpG oligodeoxynucleotides enhance the efficacy of adoptive cell transfer using tumor infiltrating lymphocytes by modifying the Th1 polarization and local infiltration of Th17 cells.
CpG oligodeoxynucleotides enhance the efficacy of adoptive cell transfer using tumor infiltrating lymphocytes by modifying the Th1 polarization and local infiltration of Th17 cells.
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CpG 寡脱氧核苷酸通过改变 Th1 极化和 Th17 细胞的局部浸润来增强肿瘤浸润淋巴细胞过继细胞转移的功效
DOI：
10.1155/2010/410893
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发表时间：
2010
影响因子：
--
通讯作者：
Ren T
中科院分区：
文献类型：
--
作者：
Xu L;Wang C;Wen Z;Zhou Y;Liu Z;Liang Y;Xu Z;Ren T
利用肿瘤浸润淋巴细胞（TIL）进行免疫转移治疗是一种重要的肿瘤治疗策略。但其疗效仍然有限，迫切需要开发新的策略。最近的证据表明CpG-ODNs可能是肿瘤免疫治疗的有效候选物。本研究首次报道CpG-ODNs能显著增强过继转染TIL的体内抗肿瘤效果，并能增强TIL对CD 8 + T细胞和CD 8 + T细胞的活性和增殖能力，以及Th 1极化免疫应答。更重要的是，CpG-ODNs能显著增加肿瘤组织中Th 17细胞的浸润，这有助于TIL体内抗肿瘤的效果。结果表明，CpG ODNs可以通过改变Th 1极化和局部Th 17细胞浸润来增强过继转染的TIL的抗肿瘤效果，这可能为开发基于TIL的ACT新策略提供线索。
Adoptive cell transfer immunotherapy using tumor infiltrating lymphocytes (TILs) was an important therapeutic strategy against tumors. But the efficacy remains limited and development of new strategies is urgent. Recent evidence suggested that CpG-ODNs might be a potent candidate for tumor immunotherapy. Here we firstly reported that CpG-ODNs could significantly enhance the antitumor efficacy of adoptively transferred TILs in vivo accompanied by enhanced activity capacity and proliferation of CD8+ T cells and CD8+ T cells, as well as a Th1 polarization immune response. Most importantly, we found that CpG-ODNs could significantly elevate the infiltration of Th17 cells in tumor mass, which contributed to anti-tumor efficacy of TILs in vivo. Our findings suggested that CpG ODNs could enhance the anti-tumor efficacy of adoptively transferred TILs through modifying Th1 polarization and local infiltration of Th17 cells, which might provide a clue for developing a new strategy for ACT based on TILs.
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影响因子：
8.6
作者：
Xu, Lin;Xu, Wei;Xiong, Sidong
通讯作者：
Xiong, Sidong
影响因子：
3.9
作者：
Mangsbo, Sara M.;Sandin, Linda C.;Totterman, Thomas H.
通讯作者：
Totterman, Thomas H.
影响因子：
11.2
作者：
Hu, Jinwei;Yuan, Xiangpeng;Yu, John S.
通讯作者：
Yu, John S.
DOI：
10.1084/jem.20090207
发表时间：
2009-07-06
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Wang L;Yi T;Kortylewski M;Pardoll DM;Zeng D;Yu H
通讯作者：
Yu H
影响因子：
4.4
作者：
Su, Xinming;Ye, Jian;Peng, Guangyong
通讯作者：
Peng, Guangyong