TREM-2 Receptor Expression Increases with 25(OH)D Vitamin Serum Levels in Patients with Pulmonary Sarcoidosis.
TREM-2 Receptor Expression Increases with 25(OH)D Vitamin Serum Levels in Patients with Pulmonary Sarcoidosis.
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DOI：
10.1155/2015/181986
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发表时间：
2015
影响因子：
4.6
通讯作者：
Tedla M
中科院分区：
文献类型：
--
作者：
Bucova M;Suchankova M;Tibenska E;Tedlova E;Demian J;Majer I;Novosadova H;Tedla M
TREM-1和TREM-2分子是TREM跨膜糖蛋白的成员。在我们先前的研究中，我们发现在肺结节病(PS)中TREM-1和TREM-2受体的表达增加。关于维生素D和TREM受体表达之间的关系的研究很少。我们目前研究的目的是确定非活性形式的25(OH)D维生素水平与TREM-1和TREM-2受体表达之间的关系。我们在79%的PS患者中检测到低水平的25(OH)D维生素。只有21%的患者血清25(OH)D维生素水平正常，其值聚集在低-正常范围内。最显著的发现是血清25(OH)D水平正常的PS患者BALF中髓系细胞表面TREM-2的表达高于血清25(OH)D水平降低的患者。25(OH)D水平正常的PS患者BALF中TREM-2阳性细胞总数是25(OH)D低水平PS患者的5.7倍，TREM-2阳性细胞百分比也显著高于25(OH)D水平低的PS患者。在总的TREM-2表达和维生素D水平之间也发现了显著的相关性。然而，我们没有检测到TREM-1的表达和25(OH)D维生素血清水平的类似差异。
TREM-1 and TREM-2 molecules are members of the TREM transmembrane glycoproteins. In our previous study we identified increased expressions of TREM-1 and TREM-2 receptors in pulmonary sarcoidosis (PS). Only a few studies concerning the association between vitamin D and TREM receptor expression can be found. The aim of our current study was to determine the association between the levels of an inactive form of 25(OH)D vitamin and TREM-1 and TREM-2 receptor expressions. We have detected low levels of 25(OH)D vitamin in 79% of PS patients. Only 21% of patients had normal serum level of 25(OH)D vitamin with values clustered within the low-normal range. The most striking findings were the increased TREM-2 expressions on myeloid cells surfaces in BALF of PS patients with normal 25(OH)D vitamin serum levels compared with those with its decreased levels. The total number of TREM-2 positive cells was 5.7 times higher and the percentage of TREM-2 positive cells was also significantly increased in BALF of PS patients with normal compared to PS patients with low 25(OH)D vitamin serum levels. A significant correlation between total TREM-2 expression and vitamin D levels has been detected too. However, we have not detected similar differences in TREM-1expression and 25(OH)D vitamin serum levels.
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影响因子：
17.1
作者：
Fabri M;Stenger S;Shin DM;Yuk JM;Liu PT;Realegeno S;Lee HM;Krutzik SR;Schenk M;Sieling PA;Teles R;Montoya D;Iyer SS;Bruns H;Lewinsohn DM;Hollis BW;Hewison M;Adams JS;Steinmeyer A;Zügel U;Cheng G;Jo EK;Bloom BR;Modlin RL
通讯作者：
Modlin RL
影响因子：
4.4
作者：
Hamerman, Jessica A.;Jarjoura, Vessica R.;Lanier, Lewis L.
通讯作者：
Lanier, Lewis L.
影响因子：
56.9
作者：
Liu, PT;Stenger, S;Modlin, RL
通讯作者：
Modlin, RL
DOI：
10.1016/j.ecl.2010.02.010
发表时间：
2010-06
影响因子：
4.5
作者：
Hewison, Martin
通讯作者：
Hewison, Martin
DOI：
10.1083/jcb.200808080
发表时间：
2009-01-26
期刊：
The Journal of cell biology
影响因子：
--
作者：
N'Diaye EN;Branda CS;Branda SS;Nevarez L;Colonna M;Lowell C;Hamerman JA;Seaman WE
通讯作者：
Seaman WE