Vitamin D and the immune system: new perspectives on an old theme.
Vitamin D and the immune system: new perspectives on an old theme.
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DOI：
10.1016/j.ecl.2010.02.010
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发表时间：
2010-06
影响因子：
4.5
通讯作者：
Hewison, Martin
中科院分区：
文献类型：
--
作者：
Hewison, Martin
与免疫系统的相互作用是维生素D最公认的非经典作用之一。多年来，这被认为是肉芽肿性疾病如结节病的表现，其中已知活性1，25-二羟基维生素D3（1，25（OH）2D 3）的合成失调。然而，最近的报道支持1，25（OH）2D 3在介导先天性和适应性免疫系统的正常功能中的作用。重要的是，这些作用似乎是通过前体25-羟基维生素D3（25 OHD 3）（维生素D的主要循环代谢产物）局部自分泌或旁分泌合成1，25（OH）2D 3介导的。因此，维生素D影响正常人体免疫力的能力将高度依赖于个体的维生素D状态，并可能导致维生素D不足的人对感染或自身免疫的异常反应。地球仪上人们对维生素D受损状况的认识不断提高，从而强调了这一问题对健康的潜在影响。下面的综述文章将更详细地描述一些关于维生素D和免疫系统的最新进展，以及可能的临床意义。
Interaction with the immune system is one of the most well-established non-classical effects of vitamin D. For many years this was considered to be a manifestation of granulomatous diseases such sarcoidosis, where synthesis of active 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) is known to be dysregulated. However, recent reports have supported a role for 1,25(OH)2D3 in mediating normal function of both the innate and adaptive immune systems. Crucially, these effects appear to be mediated via localized autocrine or paracrine synthesis of 1,25(OH)2D3 from precursor 25-hydroxyvitamin D3 (25OHD3), the main circulating metabolite of vitamin D. As such, the ability of vitamin D to influence normal human immunity will be highly dependent on the vitamin D status of individuals, and may lead to aberrant response to infection or autoimmunity in those who are vitamin D-insufficient. The potential health significance of this has been underlined by increasing awareness of impaired vitamin D status in populations across the globe. The following review article will describe in more detail some of the recent developments with respect to vitamin D and the immune system, together with possible clinical implications.
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影响因子：
158.5
作者：
BARBOUR, GL;COBURN, JW;HORST, RL
通讯作者：
HORST, RL
影响因子：
1.5
作者：
Dong, XY;Bachman, LA;Griffin, MD
通讯作者：
Griffin, MD
影响因子：
4.8
作者：
Gombart, AF;Borregaard, N;Koeffler, HP
通讯作者：
Koeffler, HP
影响因子：
4.4
作者：
Boonstra, A;Barrat, FJ;O'Garra, A
通讯作者：
O'Garra, A
DOI：
10.1073/pnas.80.18.5583
发表时间：
1983-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
ABE, E;MIYAURA, C;SUDA, T
通讯作者：
SUDA, T